Schaber Katharina, Leitzmann Michael, Pukrop Tobias, Quentin Wilm, Stein Michael J, Jochem Carmen
Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.
BMJ Open. 2025 Jan 14;15(1):e094304. doi: 10.1136/bmjopen-2024-094304.
Sedentary behaviour (SB) is associated with increased risks of breast, colorectal, endometrial, ovarian and rectal cancers. However, the number of cancer cases attributable to SB in Germany and the associated costs are unknown.
Numbers and proportions (population-attributable fractions, PAF) of new cancer cases attributable to SB with published risk estimates for Germany for the years 2024, 2030 and 2040.
Sex-specific and age-specific population projections, national cancer incidence and exposure data.
new cancer cases attributable to SB and healthcare costs associated with cancer cases attributable to SB in Germany for the year 2024.
Estimated numbers of cancers attributable to SB are projected to be up to 7612 cases (6% of total cancer cases) in 2024, up to 7899 cases (6%) in 2030 and up to 8245 cases (6%) in 2040. The PAF attributable to SB in women is 3% for breast cancer, 8% for colon cancer, 9% for both endometrial and ovarian cancers and 2% for rectal cancer. In men, the PAF is 9% for colon cancer and 3% for rectal cancer. In 2024, the estimated costs of SB-attributable cancers are €270 million for colon cancer, €51 million for rectal cancer, €234 million for breast cancer and €242 million for female genital cancers.
A considerable number of cancer cases can be attributed to SB, which also imposes a large health economic burden. Implementing effective prevention measures, such as workplace, school or commuting interventions, is needed to reduce the incidence of cancer attributable to this modifiable risk factor.
久坐行为（SB）与乳腺癌、结直肠癌、子宫内膜癌、卵巢癌和直肠癌风险增加相关。然而，德国因久坐行为导致的癌症病例数及相关成本尚不清楚。
2024年、2030年和2040年德国因久坐行为导致的新癌症病例数及比例（人群归因分数，PAF），并公布风险估计值。
按性别和年龄划分的人口预测、国家癌症发病率和暴露数据。
2024年德国因久坐行为导致的新癌症病例数以及与因久坐行为导致的癌症病例相关的医疗费用。
预计2024年因久坐行为导致的癌症病例数高达7612例（占癌症病例总数的6%），2030年高达7899例（6%），2040年高达8245例（6%）。女性因久坐行为导致的PAF在乳腺癌中为3%，结肠癌中为8%，子宫内膜癌和卵巢癌中均为9%，直肠癌中为2%。男性中，结肠癌的PAF为9%，直肠癌为3%。2024年，因久坐行为导致的癌症估计费用为：结肠癌2.7亿欧元，直肠癌5100万欧元，乳腺癌2.34亿欧元，女性生殖系统癌症2.42亿欧元。
相当数量的癌症病例可归因于久坐行为，这也带来了巨大的健康经济负担。需要实施有效的预防措施，如工作场所、学校或通勤干预措施，以降低因这种可改变的风险因素导致的癌症发病率。
