Gundula Behrens and Thomas Gredner contributed equally to this work; Hermann Brenner and Ute Mons contributed equally to this work; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty Heidelberg, University of Heidelberg, Heidelberg; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg; Cancer Prevention Unit, German Cancer Research Center (DKFZ), Heidelberg.
Dtsch Arztebl Int. 2018 Sep 3;115(35-36):578-585. doi: 10.3238/arztebl.2018.0578.
Excess weight, low physical activity, low intakes of dietary fiber, fruits, and vegetables, and high meat and salt intake increase cancer risk.
Numbers and proportions (population-attributable fractions, PAF) of incident cancer cases in Germany in 2018 attributable to these factors were estimated by sex and age groups for ages 35 to 84 years using population projections, national cancer incidence and exposure data, and published risk estimates.
Estimated numbers (percentages) of attributable cancers were 30 567 (7%) for excess weight, 27 081 (6%) for low physical activity, 14 474 (3%) for low dietary fiber intake, 9447 (2%) for low fruit and vegetable consumption, 9454 (2%) and 1687 (0.4%) for processed meat and high red meat consumption, respectively, and 1204 (0.3%) for high salt intake. Excess weight substantially contributed to endometrial, renal, and liver cancer (PAF = 24 to 35%). Low physical activity contributed to endometrial, renal, and lung cancer (PAF = 15 to 19%), and dietary factors mainly contributed to colorectal, breast, and lung cancer (PAF = 9 to 16%).
A considerable proportion of cancer cases are attributable to excess weight, physical inactivity, and unhealthy dietary habits. Major prevention efforts are needed to reduce the cancer incidence attributable to these avoidable factors.
超重、体力活动不足、膳食纤维、水果和蔬菜摄入量低、肉类和盐摄入量高都会增加癌症风险。
通过使用人口预测、国家癌症发病率和暴露数据以及已发表的风险估计,估算了 2018 年德国 35 至 84 岁人群中这些因素导致的癌症发病病例数(按性别和年龄组计算的归因分数,PAF)。
超重归因于癌症的估计病例数(百分比)为 30567 例(7%),体力活动不足为 27081 例(6%),膳食纤维摄入量低为 14474 例(3%),水果和蔬菜摄入量低为 9447 例(2%)和 9454 例(2%)和 1687 例(0.4%)和 1204 例(0.3%)分别用于高盐摄入量。超重主要导致子宫内膜癌、肾癌和肝癌(PAF = 24%至 35%)。体力活动不足主要导致子宫内膜癌、肾癌和肺癌(PAF = 15%至 19%),而饮食因素主要导致结直肠癌、乳腺癌和肺癌(PAF = 9%至 16%)。
相当一部分癌症病例归因于超重、身体活动不足和不健康的饮食习惯。需要采取重大预防措施来减少归因于这些可避免因素的癌症发病率。