Kozubowski Lukasz, Berman Judith
Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, 29634, USA.
Shmunis School of Biomedical and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.
FEMS Microbiol Rev. 2025 Jan 14;49. doi: 10.1093/femsre/fuaf001.
Phenotypic heterogeneity in genetically clonal populations facilitates cellular adaptation to adverse environmental conditions while enabling a return to the basal physiological state. It also plays a crucial role in pathogenicity and the acquisition of drug resistance in unicellular organisms and cancer cells, yet the exact contributing factors remain elusive. In this review, we outline the current state of understanding concerning the contribution of phenotypic heterogeneity to fungal pathogenesis and antifungal drug resistance.
基因克隆群体中的表型异质性有助于细胞适应不利的环境条件，同时能使其恢复到基础生理状态。它在单细胞生物和癌细胞的致病性及耐药性获得中也起着关键作用，然而确切的促成因素仍不明确。在这篇综述中，我们概述了目前对于表型异质性在真菌致病机制和抗真菌药物耐药性方面所起作用的理解现状。
