跨膜AMPA受体调节蛋白亚基γ2的结构
Structure of transmembrane AMPA receptor regulatory protein subunit γ2.
作者信息
Hale W Dylan, Romero Alejandra Montaño, Koylass Nicholas, Warrick Collin R, Qiu Zhaozhu, Huganir Richard L, Twomey Edward C
机构信息
Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Nat Commun. 2025 Jan 15;16(1):671. doi: 10.1038/s41467-025-56027-1.
Transmembrane AMPA receptor regulatory proteins (TARPs) are claudin-like proteins that tightly regulate AMPA receptors (AMPARs) and are fundamental for excitatory neurotransmission. With cryo-electron microscopy (cryo-EM) we reconstruct the 36 kDa TARP subunit γ2 to 2.3 Å, which points to structural diversity among TARPs. Our data reveals critical motifs that distinguish TARPs from claudins and define how sequence variations within TARPs differentiate subfamilies and their regulation of AMPARs.
跨膜AMPA受体调节蛋白（TARPs）是紧密调节AMPA受体（AMPARs）的claudin样蛋白，对兴奋性神经传递至关重要。通过冷冻电子显微镜（cryo-EM），我们将36 kDa的TARP亚基γ2重建至2.3 Å，这表明TARPs之间存在结构多样性。我们的数据揭示了区分TARPs与claudins的关键基序，并确定了TARPs内的序列变异如何区分亚家族及其对AMPARs的调节。
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