Cai Haojun, Mu Qianqian, Xiong Haiting, Liu Meichen, Yang Fengjiao, Zhou Ling, Zhou Biying
School of Basic Medicine, Zunyi Medical University, Zunyi, China.
Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Parasitol Res. 2025 Jan 15;124(1):5. doi: 10.1007/s00436-024-08450-4.
Parasitic infection is a complex process involving interactions among various immune cells. Regulatory B cells (Breg cells), a subset of B lymphocytes with immunosuppressive functions, play a role in modulating immune responses during infection to prevent excessive immune activation. This article reviews the origin, phenotype, and immunoregulatory mechanisms of Breg cells. We summarize the immunomodulatory roles of Breg cells in various parasitic infections. We also discuss the potential applications of activating Breg cells through parasitic infections and their derived molecules in the treatment of certain allergic, autoimmune, and inflammatory diseases. The aim is to provide new perspectives for the future treatment of parasitic diseases and other related conditions.
寄生虫感染是一个复杂的过程，涉及多种免疫细胞之间的相互作用。调节性B细胞（Breg细胞）是具有免疫抑制功能的B淋巴细胞亚群，在感染期间调节免疫反应以防止过度免疫激活中发挥作用。本文综述了Breg细胞的起源、表型和免疫调节机制。我们总结了Breg细胞在各种寄生虫感染中的免疫调节作用。我们还讨论了通过寄生虫感染及其衍生分子激活Breg细胞在治疗某些过敏性、自身免疫性和炎症性疾病中的潜在应用。目的是为未来寄生虫病及其他相关病症的治疗提供新的视角。
