核苷酸对鲎腹侧光感受器中自发量子突增速率的影响。
The effect of nucleotides on the rate of spontaneous quantum bumps in Limulus ventral photoreceptors.
作者信息
Stern J, Chinn K, Robinson P, Lisman J
出版信息
J Gen Physiol. 1985 Feb;85(2):157-69. doi: 10.1085/jgp.85.2.157.
Abstract
The effect of intracellular nucleotides on the rate of spontaneous quantum bumps in Limulus ventral photoreceptors has been examined. Internal dialysis of photoreceptors with solutions lacking nucleotide leads to an elevation of the quantum bump rate that can be reversed by introduction of nucleotide. Similarly, elevation occurs after treating intact cells with the metabolic inhibitor 2-deoxyglucose. This effect can be reversed by intracellular injection of ATP. The rate of spontaneous quantum bumps in unpoisoned cells can be reduced to below normal levels by injection of ATP. These results support the hypothesis that high-energy nucleotides suppress the rate of spontaneous quantum bumps.
摘要
已经研究了细胞内核苷酸对鲎腹侧光感受器中自发光子脉冲频率的影响。用缺乏核苷酸的溶液对光感受器进行内部透析会导致光子脉冲频率升高，而引入核苷酸可使其逆转。同样，用代谢抑制剂2-脱氧葡萄糖处理完整细胞后也会出现频率升高。通过细胞内注射ATP可逆转这种效应。通过注射ATP，未中毒细胞中的自发光子脉冲频率可降低至正常水平以下。这些结果支持了高能核苷酸抑制自发光子脉冲频率的假说。
相似文献
1
The effect of nucleotides on the rate of spontaneous quantum bumps in Limulus ventral photoreceptors.
J Gen Physiol. 1985 Feb;85(2):157-69. doi: 10.1085/jgp.85.2.157.
2
Internal dialysis of Limulus ventral photoreceptors.
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7580-4. doi: 10.1073/pnas.79.23.7580.
3
Non-independent quantum bumps in Limulus ventral nerve photoreceptors--a new insight in the light transduction mechanism.
Neurosci Lett. 1992 Sep 14;144(1-2):99-102. doi: 10.1016/0304-3940(92)90725-m.
4
The role of metarhodopsin in the generation of spontaneous quantum bumps in ultraviolet receptors of Limulus median eye. Evidence for reverse reactions into an active state.
J Gen Physiol. 1985 Feb;85(2):171-87. doi: 10.1085/jgp.85.2.171.
5
Circadian rhythms in Limulus photoreceptors. II. Quantum bumps.
J Gen Physiol. 1990 Sep;96(3):665-85. doi: 10.1085/jgp.96.3.665.
6
Flash photolysis of caged compounds in Limulus ventral photoreceptors.
J Gen Physiol. 1992 Sep;100(3):547-70. doi: 10.1085/jgp.100.3.547.
7
Circadian change in function of Limulus ventral photoreceptors.
Vis Neurosci. 1988;1(1):3-11. doi: 10.1017/s0952523800000985.
8
Adapting bump model for ventral photoreceptors of Limulus.
J Gen Physiol. 1982 Jun;79(6):1089-113. doi: 10.1085/jgp.79.6.1089.
9
Efferent neurotransmission of circadian rhythms in Limulus lateral eye. II. Intracellular recordings in vitro.
J Comp Physiol A. 1988 Nov;164(1):95-105. doi: 10.1007/BF00612723.
10
The quantal source of area supralinearity of flash responses in Limulus photoreceptors.
J Gen Physiol. 1988 May;91(5):659-84. doi: 10.1085/jgp.91.5.659.
引用本文的文献
1
The role of metarhodopsin in the generation of spontaneous quantum bumps in ultraviolet receptors of Limulus median eye. Evidence for reverse reactions into an active state.
J Gen Physiol. 1985 Feb;85(2):171-87. doi: 10.1085/jgp.85.2.171.
2
The response to monochromatic light flashes of the oxygen consumption of honeybee drone photoreceptors.
J Gen Physiol. 1987 May;89(5):791-813. doi: 10.1085/jgp.89.5.791.
3
Chemical excitation and inactivation in photoreceptors of the fly mutants trp and nss.
J Gen Physiol. 1989 Sep;94(3):465-91. doi: 10.1085/jgp.94.3.465.
4
Efferent neurotransmission of circadian rhythms in Limulus lateral eye. II. Intracellular recordings in vitro.
J Comp Physiol A. 1988 Nov;164(1):95-105. doi: 10.1007/BF00612723.
5
Electrophysiological properties of isolated photoreceptors from the eye of Lima scabra.
J Gen Physiol. 1991 Jan;97(1):17-34. doi: 10.1085/jgp.97.1.17.
本文引用的文献
1
The visual cell: electric and metabolic manifestations of its life processes.
Am J Ophthalmol. 1959 Nov;48(5)Pt 2:347-70. doi: 10.1016/0002-9394(59)90589-6.
2
SPONTANEOUS SLOW POTENTIAL FLUCTUATIONS IN THE LIMULUS PHOTORECEPTOR.
J Gen Physiol. 1964 Nov;48(2):297-322. doi: 10.1085/jgp.48.2.297.
3
THE INFLUENCE OF 2-DEOXY-D-GLUCOSE ON THE NUCLEOTIDE CONTENT OF EHRLICH ASCITES CARCINOMA CELLS.
Biochim Biophys Acta. 1964 May 18;87:1-8. doi: 10.1016/0926-6550(64)90040-4.
4
Light dependent phosphorylation of rhodopsin by ATP.
FEBS Lett. 1972 Jan 15;20(1):1-6. doi: 10.1016/0014-5793(72)80002-4.
5
Increase in intracellular free calcium concentration of Limulus photoreceptors caused by a metabolic inhibitor.
Vision Res. 1980;20(6):539-44. doi: 10.1016/0042-6989(80)90129-7.
6
The pH dependence of discrete wave frequency in Limulus ventral photoreceptors.
Brain Res. 1980 Jul 14;193(2):558-61. doi: 10.1016/0006-8993(80)90188-2.
7
Diamide, a sulfhydryl reagent, modifies the light response of Limulus ventral photoreceptors.
Neurosci Lett. 1981 Jan 20;21(2):165-70. doi: 10.1016/0304-3940(81)90376-1.
8
Distinct lobes of Limulus ventral photoreceptors. I. Functional and anatomical properties of lobes revealed by removal of glial cells.
J Gen Physiol. 1982 Dec;80(6):825-37. doi: 10.1085/jgp.80.6.825.
9
Epithelial cell motility: the effect of 2-deoxyglucose on cell migration, ATP production, and the structure of the cytoplasmic ground substance in lamellipodia of epithelial cells in culture.
Cell Motil. 1982;2(1):25-46. doi: 10.1002/cm.970020104.
10
Injection of guanosine and adenosine nucleotides into Limulus ventral photoreceptor cells.
J Physiol. 1982 Nov;332:325-42. doi: 10.1113/jphysiol.1982.sp014416.
Zotero 插件