核苷酸对鲎腹侧光感受器中自发量子突增速率的影响。
The effect of nucleotides on the rate of spontaneous quantum bumps in Limulus ventral photoreceptors.
作者信息
Stern J, Chinn K, Robinson P, Lisman J
出版信息
J Gen Physiol. 1985 Feb;85(2):157-69. doi: 10.1085/jgp.85.2.157.
Abstract
The effect of intracellular nucleotides on the rate of spontaneous quantum bumps in Limulus ventral photoreceptors has been examined. Internal dialysis of photoreceptors with solutions lacking nucleotide leads to an elevation of the quantum bump rate that can be reversed by introduction of nucleotide. Similarly, elevation occurs after treating intact cells with the metabolic inhibitor 2-deoxyglucose. This effect can be reversed by intracellular injection of ATP. The rate of spontaneous quantum bumps in unpoisoned cells can be reduced to below normal levels by injection of ATP. These results support the hypothesis that high-energy nucleotides suppress the rate of spontaneous quantum bumps.
摘要
已经研究了细胞内核苷酸对鲎腹侧光感受器中自发光子脉冲频率的影响。用缺乏核苷酸的溶液对光感受器进行内部透析会导致光子脉冲频率升高，而引入核苷酸可使其逆转。同样，用代谢抑制剂2-脱氧葡萄糖处理完整细胞后也会出现频率升高。通过细胞内注射ATP可逆转这种效应。通过注射ATP，未中毒细胞中的自发光子脉冲频率可降低至正常水平以下。这些结果支持了高能核苷酸抑制自发光子脉冲频率的假说。
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Injection of guanosine and adenosine nucleotides into Limulus ventral photoreceptor cells.向鲎腹侧感光细胞注射鸟苷酸和腺苷酸。
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