Ichimura H, Shimase K, Tamura I, Kaneto E, Kurimura O, Aramitsu Y, Kurimura T
J Med Virol. 1985 Mar;15(3):231-7. doi: 10.1002/jmv.1890150304.
Cerebrospinal fluids (CSFs) and sera from 20 patients with echovirus 30 (E 30) meningitis, 4 patients with enterovirus 71 (EV 71) meningitis, and 5 patients with acute aseptic meningitis (AM) of unknown etiology were investigated at the acute and the convalescent phases of the disease to elucidate the roles of neutralizing antibody (NT) and interferon-alpha (IFN-alpha) in the central nervous system (CNS) in cases of AM in humans. Viruses were isolated from the CSFs at the acute phase of AM, but not at the convalescent phase. There was a fourfold or greater rise in NT titer between paired sera to E 30 or EV 71 but only a slight rise between paired CSFs. IFN-alpha was detected in the CSFs ranging from less than 10 to 25.5 IU/ml but not in the sera, and the IFN-alpha level in the CSF was significantly higher in the acute phase than in the convalescent phase. These results suggest that in cases of acute enteroviral infections in the CNS, NT plays only a small role in the recovery from AM, and IFN-alpha plays a direct or indirect role in curbing the local spread of the virus and eliminating the virus from the CNS at the acute phase of AM.
对20例肠道病毒30型（E30）脑膜炎患者、4例肠道病毒71型（EV71）脑膜炎患者以及5例病因不明的急性无菌性脑膜炎（AM）患者在疾病的急性期和恢复期采集脑脊液（CSF）和血清，以阐明中和抗体（NT）和α干扰素（IFN-α）在人类AM病例中枢神经系统（CNS）中的作用。在AM急性期从CSF中分离出病毒，但在恢复期未分离出。配对血清对E30或EV71的NT滴度有四倍或更高的升高，但配对CSF之间仅有轻微升高。在CSF中检测到IFN-α，范围为小于10至25.5 IU/ml，但血清中未检测到，且CSF中IFN-α水平在急性期显著高于恢复期。这些结果表明，在CNS急性肠道病毒感染病例中，NT在AM恢复中仅起很小的作用，而IFN-α在AM急性期抑制病毒局部传播和从CNS清除病毒方面起直接或间接作用。
