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使用硼氢化钠和氯化铜（II）将β-硝基苯乙烯轻松一锅法还原为苯乙胺。

Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride.

作者信息

D'Andrea Laura, Jademyr Simon

机构信息

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 København Ø, Denmark.

current address: Department of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, 9220 Aalborg, Denmark.

出版信息

Beilstein J Org Chem. 2025 Jan 7;21:39-46. doi: 10.3762/bjoc.21.4. eCollection 2025.

DOI:10.3762/bjoc.21.4
PMID:39811686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11729678/
Abstract

Phenethylamines and phenylisopropylamines of scientific relevance can be prepared with a NaBH/CuCl system in 10 to 30 minutes via reduction of substituted β-nitrostyrenes. This one-pot procedure allows the quick isolation of substituted β-nitrostyrene scaffolds with 62-83% yield under mild conditions, without the need for special precautions, inert atmosphere, and time-consuming purification techniques.

摘要

具有科学相关性的苯乙胺和苯异丙胺可通过NaBH/CuCl体系，在10至30分钟内通过还原取代的β-硝基苯乙烯来制备。这种一锅法可在温和条件下快速分离出取代的β-硝基苯乙烯支架，产率为62-83%，无需特殊防护措施、惰性气氛和耗时的纯化技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d947/11729678/d49627fda904/Beilstein_J_Org_Chem-21-39-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d947/11729678/ed6f2061f53c/Beilstein_J_Org_Chem-21-39-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d947/11729678/b254cff87f15/Beilstein_J_Org_Chem-21-39-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d947/11729678/b7815e29d955/Beilstein_J_Org_Chem-21-39-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d947/11729678/c50b6d1d54a3/Beilstein_J_Org_Chem-21-39-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d947/11729678/d111322efd80/Beilstein_J_Org_Chem-21-39-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d947/11729678/d49627fda904/Beilstein_J_Org_Chem-21-39-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d947/11729678/ed6f2061f53c/Beilstein_J_Org_Chem-21-39-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d947/11729678/b254cff87f15/Beilstein_J_Org_Chem-21-39-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d947/11729678/b7815e29d955/Beilstein_J_Org_Chem-21-39-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d947/11729678/c50b6d1d54a3/Beilstein_J_Org_Chem-21-39-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d947/11729678/d111322efd80/Beilstein_J_Org_Chem-21-39-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d947/11729678/d49627fda904/Beilstein_J_Org_Chem-21-39-g007.jpg

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