使用硼氢化钠和氯化铜（II）将β-硝基苯乙烯轻松一锅法还原为苯乙胺。

Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride.

作者信息

D'Andrea Laura, Jademyr Simon

机构信息

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 København Ø, Denmark.

current address: Department of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, 9220 Aalborg, Denmark.

出版信息

Beilstein J Org Chem. 2025 Jan 7;21:39-46. doi: 10.3762/bjoc.21.4. eCollection 2025.

Phenethylamines and phenylisopropylamines of scientific relevance can be prepared with a NaBH/CuCl system in 10 to 30 minutes via reduction of substituted β-nitrostyrenes. This one-pot procedure allows the quick isolation of substituted β-nitrostyrene scaffolds with 62-83% yield under mild conditions, without the need for special precautions, inert atmosphere, and time-consuming purification techniques.