Terao Caitlin M, Alexander Madeline Wood, Chalmers R Philip, Boshmaf Silina Z, Paterson Jane, Black Sandra E, Papp Kathryn V, Sperling Reisa A, Rabin Jennifer S
Hurvitz Brain Sciences Program Sunnybrook Research Institute Toronto Ontario Canada.
Department of Psychology, York University Toronto Ontario Canada.
Alzheimers Dement (Amst). 2025 Jan 14;17(1):e70052. doi: 10.1002/dad2.70052. eCollection 2025 Jan-Mar.
This study aimed to identify cognitive tests that optimally relate to tau positron emission tomography (PET) signal in the inferior temporal cortex (ITC), a neocortical region associated with early tau accumulation in Alzheimer's disease (AD).
We analyzed cross-sectional data from the harvard aging brain study (HABS) (= 128) and the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) study (= 393). We used elastic net regression to identify the most robust cognitive correlates of tau PET signal in the ITC. Secondary analyses examined whether the cognitive correlates remained significantly associated with tau after adjusting for structural brain measures.
Episodic memory measures, including both total and "process" scores, were the most robust correlates of ITC tau across both cohorts. These cognitive test scores remained significant after accounting for structural brain measures.
These findings highlight the potential of specific episodic memory test scores to detect and monitor neuropathological changes associated with early AD.
Machine learning identified cognitive correlates of early Alzheimer's disease tau burden.Both traditional and process scores predicted early tau burden.Episodic memory scores were among the strongest correlates.Cognitive scores remained significant after accounting for structural brain measures.
本研究旨在确定与颞下回（ITC）中tau正电子发射断层扫描（PET）信号最相关的认知测试，ITC是与阿尔茨海默病（AD）早期tau积累相关的新皮质区域。
我们分析了来自哈佛衰老大脑研究（HABS，n = 128）和无症状阿尔茨海默病抗淀粉样蛋白治疗（A4）研究（n = 393）的横断面数据。我们使用弹性网络回归来确定ITC中tau PET信号最可靠的认知相关性。二次分析检验了在调整脑结构测量指标后，认知相关性是否仍与tau显著相关。
情景记忆测量指标，包括总分和“过程”分数，是两个队列中ITC tau最可靠的相关性指标。在考虑脑结构测量指标后，这些认知测试分数仍然具有显著性。
这些发现凸显了特定情景记忆测试分数在检测和监测与早期AD相关的神经病理变化方面的潜力。
机器学习确定了早期阿尔茨海默病tau负担的认知相关性。传统分数和过程分数均能预测早期tau负担。情景记忆分数是最强的相关性指标之一。在考虑脑结构测量指标后，认知分数仍然具有显著性。
