Shen Chao, Ding Xiaoyan, Rao Wenhua, Hu Jinfeng, Lin Tao, Zhou Xian-Zhi, Zheng Yongquan, Dong Fengshou, Fan Guocheng
Fujian Engineering Research Center for Green Pest Management/Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests/East China Branch of the National Center for Agricultural Biosafety Sciences, Institute of Plant Protection, Fujian Academy of Agricultural Sciences, Fuzhou 350013, China.
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China.
J Agric Food Chem. 2025 Jan 15;73(2):1167-1181. doi: 10.1021/acs.jafc.4c09545. Epub 2024 Dec 31.
Azole and benzimidazole fungicides are widely used agrochemicals to prevent and treat fungal growth and are frequently detected in aquatic environments. Here, we aimed to assess the aquatic ecological risks of ten currently used azole and benzimidazole fungicides, which with the aryl hydrocarbon receptor (AhR) agonistic activity, and their transformation products (TPs). We obtained over 400 types of aerobic TPs for ten fungicides. Some fungicides and their TPs (approximately 26.7%) exhibited the potential AhR agonistic activity and toxicity to different aquatic species. Meanwhile, some compounds with the chlorine element and benzene ring structure exhibited environmental persistence and mobile ability. Several of them were frequently detected in aquatic environments, posing potential risks to aquatic ecosystems. These harmful fungicides and their TPs should be given attention. This study provides important insight into the aquatic ecological risks caused by azole and benzimidazole fungicides, which can provide theoretical guidance for their pollution control.
唑类和苯并咪唑类杀菌剂是广泛使用的农用化学品，用于预防和治疗真菌生长，并且经常在水生环境中被检测到。在此，我们旨在评估十种目前使用的具有芳烃受体（AhR）激动活性的唑类和苯并咪唑类杀菌剂及其转化产物（TPs）的水生生态风险。我们获得了十种杀菌剂的400多种需氧TPs。一些杀菌剂及其TPs（约26.7%）对不同水生物种表现出潜在的AhR激动活性和毒性。同时，一些含有氯元素和苯环结构的化合物表现出环境持久性和迁移能力。其中几种在水生环境中经常被检测到，对水生生态系统构成潜在风险。这些有害杀菌剂及其TPs应予以关注。本研究为唑类和苯并咪唑类杀菌剂引起的水生生态风险提供了重要见解，可为其污染控制提供理论指导。
