Hegde R P, Rheingold J L, Welch S, Rhodes C T
J Pharm Sci. 1985 Jan;74(1):11-5. doi: 10.1002/jps.2600740104.
This paper describes the utility of the dynamic measurement of the angle of repose for pharmaceutical systems, using a variable rotating cylinder to quantify powder flow. The dynamic angle of repose of sodium chloride powder sieve fractions was evaluated using a variable rotating cylinder. The relationship between the static and the dynamic angle of repose is discussed. The dynamic angle of repose of six lots of a multivitamin preparation were compared for inter- and intralot variation. In both cases, no significant differences (p greater than 0.05) were observed. In the multivitamin formulation, lubricants at lower concentration levels did not show a significant effect (p greater than 0.05) on the dynamic angle of repose when compared with flow rates. The effect of different hopper sizes and geometry has been evaluated using the recording powder flowmeter. The results indicate that although different hoppers affect the quantitative nature of the results, the same general trends are apparent. Thus, it appears possible to use a recording powder flowmeter with small quantities of material to predict the effect of formulation and processing variables on the flow of production scale quantities. This paper does not describe a comprehensive evaluation of the pharmaceutical utility of measuring the dynamic angle of repose. However, the results discussed are not encouraging and suggest that the recording powder flowmeter is more sensitive to the effects of formulation and production variables on powder flow.
本文描述了使用可变旋转圆筒来量化粉末流动，从而对药物系统休止角进行动态测量的实用性。使用可变旋转圆筒评估了氯化钠粉末筛分级分的动态休止角。讨论了静态和动态休止角之间的关系。比较了六批多种维生素制剂的动态休止角，以考察批次间和批次内的差异。在这两种情况下，均未观察到显著差异（p大于0.05）。在多种维生素制剂中，与流速相比，较低浓度水平的润滑剂对动态休止角未显示出显著影响（p大于0.05）。使用记录式粉末流量计评估了不同料斗尺寸和几何形状的影响。结果表明，尽管不同的料斗会影响结果的定量性质，但相同的总体趋势是明显的。因此，似乎可以使用记录式粉末流量计对少量物料进行测量，以预测制剂和加工变量对生产规模物料流动的影响。本文并未描述对测量动态休止角的药物实用性的全面评估。然而，所讨论的结果并不乐观，表明记录式粉末流量计对制剂和生产变量对粉末流动的影响更为敏感。
