湿法制粒的流速和休止角。
Flow rates and repose angles of wet-processed granulations.
作者信息
Carstensen J T, Chan P C
出版信息
J Pharm Sci. 1977 Sep;66(9):1235-8. doi: 10.1002/jps.2600660907.
PMID:903857
Abstract
The equation of McDougall and Evans was found not to apply to granulations. The functional relationships among volumetric powder flow rates, angles of repose, and particle size were demonstrated to exhibit maxima (rather than minima) in five common pharmaceutical granulations produced by wet processing. The angular behavior of granules (such as the experienced range of angles) is explained via supported stacking geometries, and the shallow maxima in the angle of repose versus granule diameter was derived from this model.
摘要
发现麦克杜格尔和埃文斯的公式不适用于颗粒。在通过湿法制得的五种常见药物颗粒中，体积粉末流速、休止角和粒径之间的函数关系呈现出最大值（而非最小值）。颗粒的角行为（如经历的角度范围）通过支持的堆积几何形状来解释，休止角与颗粒直径关系中的浅最大值由此模型推导得出。
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