Witbracht Megan, Xu Yiren, Morgan Olivia B, Salazar Christian R, Hoang Dan, Kind Amy, Gillen Daniel L, Grill Joshua D
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Department of Statistics, University of California, Irvine, Irvine, CA, USA.
J Alzheimers Dis. 2025 Jan;103(2):406-418. doi: 10.1177/13872877241302422. Epub 2025 Jan 15.
Recruitment registries are maximally effective when registrants are retained to the point of referral. The Research Attitudes Questionnaire (RAQ) has previously been shown to predict research participation behaviors, including Alzheimer's disease clinical trial completion.
To test the hypothesis that RAQ score is associated with retention behaviors in a local recruitment registry.
Using data from the UC Irvine Consent-to-Contact Registry, a recruitment registry that enrolls adults 18 years and older, we used logistic regression to quantify the association of RAQ score and the odds of first-year non-renewal. Covariates included demographic variables, comorbidities, and recruitment source. In longitudinal analyses, we used discrete proportional hazards and Cox proportional hazards models to quantify the relationship between RAQ score and time to non-renewal and time to active withdrawal, respectively.
Among n = 4663 participants, we estimated that a 5-point higher baseline RAQ score was associated with a 15% lower odds of first-year non-renewal, after adjustment for potential confounding factors (OR: 0.85, 95% CI: (0.79, 0.92), p < 0.001). Older age and higher education were also associated with lower odds of non-renewal while Asian race, Hispanic ethnicity, and certain recruitment sources (e.g., doctor or friend referral) were associated with higher odds of non-renewal. Higher baseline RAQ and higher annually updated RAQ were both significantly associated with lower odds of non-renewal longitudinally. Age, education, and some recruitment sources, but not RAQ, were associated with active withdrawal.
Opportunities exist to identify predictors of registry retention behaviors and possible targets for intervention to improve related outcomes.
当登记参与者被保留到转诊阶段时，招募登记系统的效果最佳。研究态度问卷（RAQ）先前已被证明可预测研究参与行为，包括阿尔茨海默病临床试验的完成情况。
检验RAQ评分与当地招募登记系统中保留行为相关的假设。
利用加州大学欧文分校同意接触登记系统的数据，该登记系统招募18岁及以上的成年人，我们使用逻辑回归来量化RAQ评分与第一年不续约几率之间的关联。协变量包括人口统计学变量、合并症和招募来源。在纵向分析中，我们分别使用离散比例风险模型和Cox比例风险模型来量化RAQ评分与不续约时间和主动退出时间之间的关系。
在n = 4663名参与者中，我们估计，在调整潜在混杂因素后，基线RAQ评分每高5分，第一年不续约的几率就会降低15%（OR：0.85，95%CI：(0.79, 0.92)，p < 0.001）。年龄较大和受教育程度较高也与较低的不续约几率相关，而亚洲种族、西班牙裔和某些招募来源（如医生或朋友推荐）与较高的不续约几率相关。纵向来看，较高的基线RAQ和每年更新的较高RAQ均与较低的不续约几率显著相关。年龄、教育程度和一些招募来源与主动退出有关，但与RAQ无关。
存在识别登记系统保留行为预测因素以及改善相关结果的可能干预目标的机会。
