Akyüz İpek Eraslan, Eminsoy Avcı Ayşe Tuğba, Üstün Yakup, Kolçakoğlu Kevser Solak, Kızılcı Esra
Department of Endodontics, Faculty of Dentistry, Erciyes University, Melikgazi, Kayseri, 38039, Türkiye.
Department of Pedodontics, Faculty of Dentistry, Erciyes University, 38039, Kayseri, Türkiye.
Clin Oral Investig. 2025 Jan 16;29(1):66. doi: 10.1007/s00784-025-06153-3.
This study evaluates the effect of different irrigation solutions for postoperative pain in the regenerative endodontic treatments (RET) of necrotic teeth with open apex.
This study included necrotic, deeply carious lower molars of 42 patients. Access cavities of the teeth were opened and working lengths were measured at the first visit. In Group 1, the root canals were irrigated with 1.5% sodium hypochlorite (NaOCl) and 17% Ethylenediaminetetraacetic-acid (EDTA), in Group 2, with 1.5% NaOCl and 10% citric acid, and in the Group 3, with 1.5% NaOCl and 9% Etidronic acid (HEDP) mixture solution. Final irrigation was performed with distilled water. The canals were dried, filled with calcium hydroxide paste, and sealed with Cavit. Postoperative pain was assessed using a numerical rating scale, and Paracetamol was prescribed. At the second visit, calcium hydroxide was removed with 1.5% NaOCl, irrigated with chelators, and sealed with Sure-Seal PT 3 mm below the cementoenamel junction before composite resin filling.
Postoperative pain was higher in Group 3 (p < 0.05), but analgesic consumption did not show a significant difference (p > 0.05).
HEDP caused significantly more postoperative pain than EDTA and citric acid (p < 0.05). While the study provided information regarding the effects of irrigation solutions on postoperative pain, further research is needed as it did not include detailed assessments of long-term periapical healing and apex closure.
When HEDP is used as a chelation agent in RETs, it shows a higher degree of postoperative pain than EDTA and citric acid solutions.
The study protocol was registered at www.
gov (ID: NCT06386991).
本研究评估不同冲洗液对根尖开放的坏死牙进行再生性牙髓治疗（RET）术后疼痛的影响。
本研究纳入了42例患者的坏死、深龋下磨牙。首次就诊时开髓并测量工作长度。第1组根管用1.5%次氯酸钠（NaOCl）和17%乙二胺四乙酸（EDTA）冲洗，第2组用1.5% NaOCl和10%柠檬酸冲洗，第3组用1.5% NaOCl和9%依替膦酸（HEDP）混合溶液冲洗。最后用蒸馏水冲洗。根管干燥后，用氢氧化钙糊剂充填，并用Cavit封闭。采用数字评分量表评估术后疼痛，并开具对乙酰氨基酚。第二次就诊时，用1.5% NaOCl去除氢氧化钙，用螯合剂冲洗，在复合树脂充填前在牙骨质釉质界下方3 mm处用Sure-Seal封闭。
第3组术后疼痛更严重（p < 0.05），但镇痛药消耗量无显著差异（p > 0.05）。
HEDP引起的术后疼痛明显多于EDTA和柠檬酸（p < 0.05）。虽然本研究提供了关于冲洗液对术后疼痛影响的信息，但由于未包括对长期根尖周愈合和根尖闭合的详细评估，仍需进一步研究。
在RET中使用HEDP作为螯合剂时，其术后疼痛程度高于EDTA和柠檬酸溶液。
