Zhang Yiwei, Gan Xiaoqin, Xiang Hao, Zhang Yanjun, Yang Sisi, Ye Ziliang, Huang Yu, Wu Yiting, Mai Jinsheng, Jiang Jianping, Qin Xianhui, Zhang Yuanyuan
Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, 510515, China.
Mol Nutr Food Res. 2025 Feb;69(4):e202400761. doi: 10.1002/mnfr.202400761. Epub 2025 Jan 15.
The relationship of dietary copper intake with new-onset chronic kidney disease (CKD) remained unclear. We aimed to examine the association of dietary copper intake with new-onset CKD in a 30-year follow-up study from young adulthood to midlife.
A total of 4038 U.S. adults aged 18-30 years and without reduced estimated glomerular filtration rate (eGFR) from the Coronary Artery Risk Development in Young Adults (CARDIA) study was included. During a 30-year follow-up, 642 (15.9%) participants developed new-onset CKD. Overall, there was a U-shaped relationship between dietary copper intake and new-onset CKD (p for nonlinearity = 0.034). When copper intake was assessed as quartiles, compared with those in the second quartile (2.03-<2.46 mg/day), the adjusted hazard ratios (HRs) (95% confidence interval [CI]) for new-onset CKD were 1.29 (1.05, 1.66), 1.29 (1.02, 1.64), and 1.49 (1.16, 1.91) for participants in the first (<2.03 mg/day), third (2.46-<3.11 mg/day), and fourth (≥3.11 mg/day) quartiles, respectively. Similar U-shaped associations were observed for new-onset eGFR decline and albuminuria.
There was a U-shaped relationship of dietary total copper intake with new-onset CKD, with the lowest risk at a dietary copper intake of 2.03-<2.46 mg/day. Emphasizing the importance of maintaining optimal copper intake levels for the primary prevention of CKD.
饮食中铜摄入量与新发慢性肾脏病（CKD）之间的关系仍不明确。我们旨在通过一项从青年期到中年期的30年随访研究，探讨饮食中铜摄入量与新发CKD之间的关联。
纳入了来自青年动脉粥样硬化风险发展研究（CARDIA）的4038名18 - 30岁且估计肾小球滤过率（eGFR）未降低的美国成年人。在30年的随访期间，642名（15.9%）参与者出现了新发CKD。总体而言，饮食中铜摄入量与新发CKD之间呈U型关系（非线性p值 = 0.034）。当将铜摄入量评估为四分位数时，与第二四分位数（2.03 - <2.46毫克/天）的参与者相比，第一（<2.03毫克/天）、第三（2.46 - <3.11毫克/天）和第四（≥3.11毫克/天）四分位数的参与者新发CKD的调整后风险比（HRs）（95%置信区间[CI]）分别为1.29（1.05，1.66）、1.29（1.02，1.64）和1.49（1.16，1.91）。新发eGFR下降和蛋白尿也观察到类似的U型关联。
饮食中总铜摄入量与新发CKD呈U型关系，饮食铜摄入量为2.03 - <2.46毫克/天时风险最低。强调维持最佳铜摄入量水平对CKD一级预防的重要性。
