Achdiat Pati Aji, Larasati Ranisa, Hidayah Risa Miliawati Nurul, Avriyanti Erda, Usman Hermin Aminah, Maharani Retno Hesty
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Int Med Case Rep J. 2025 Jan 11;18:67-74. doi: 10.2147/IMCRJ.S494454. eCollection 2025.
Verruca vulgaris is a cutaneous infection predominantly caused by human papillomavirus (HPV) type 1, 2, and 4. In immunocompromised individuals infected with human immunodeficiency virus (HIV) infection, HPV leads to a higher prevalence of infections and also has a greater likelihood of being infected with atypical types such as genital-associated HPV in extragenital sites. This case report describes a 48-year-old male patient who presented with skin-colored verrucous papules on the hands and feet, with no evidence of genital lesions. Polymerase Chain Reaction (PCR) genotyping identified the presence of HPV types 4, 6, and 16 as an etiology of verruca vulgaris, low-risk HPV with genital-associated lesions, and high-risk HPV. This atypical result may suggest a failure of the immune defense system of the body. Therefore, accurately identifying HPV types through PCR testing in immunocompromised patients is essential for appropriate clinical management and monitoring.
寻常疣是一种主要由1、2和4型人乳头瘤病毒（HPV）引起的皮肤感染。在感染人类免疫缺陷病毒（HIV）的免疫功能低下个体中，HPV导致感染的患病率更高，并且在生殖器外部位感染非典型类型（如与生殖器相关的HPV）的可能性也更大。本病例报告描述了一名48岁男性患者，其手部和足部出现肤色疣状丘疹，无生殖器病变迹象。聚合酶链反应（PCR）基因分型确定4、6和16型HPV是寻常疣、伴有生殖器相关病变的低风险HPV以及高风险HPV的病因。这种非典型结果可能提示机体免疫防御系统功能失效。因此，通过PCR检测在免疫功能低下患者中准确鉴定HPV类型对于适当的临床管理和监测至关重要。
