Marcinkowska Anna B, Kucewicz Michal T, Szarmach Arkadiusz, Winklewski Pawel J
Applied Cognitive Neuroscience Lab, Department of Neurophysiology, Neuropsychology and Neuroinformatics, Medical University of Gdansk, Gdansk, Poland.
2nd Department of Radiology, Medical University of Gdansk, Gdansk, Poland.
Curr Neuropharmacol. 2025;23(9):1036-1046. doi: 10.2174/011570159X340612241121072233.
The dorsolateral prefrontal cortex (dlPFC) is increasingly targeted by various noninvasive transcranial magnetic stimulation or transcranial current stimulation protocols in a range of neuropsychiatric and other brain disorders. The rationale for this therapeutic modulation remains elusive. A model is proposed, and up-to-date evidence is discussed, suggesting that the dlPFC is a high-level cortical centre where uncertainty management, movement facilitation, and cardiovascular control processes are intertwined and integrated to deliver optimal behavioural responses in particular environmental or emotional contexts. A summary of the state-of-the-art in the field is provided to accelerate the development of emerging neuromodulation technologies for brain stimulation and recording for patients with mood, sleep, and cognitive disorders in our ageing population.
在一系列神经精神疾病和其他脑部疾病中，背外侧前额叶皮层（dlPFC）越来越多地成为各种非侵入性经颅磁刺激或经颅电流刺激方案的靶点。这种治疗性调节的基本原理仍然难以捉摸。本文提出了一个模型，并讨论了最新证据，表明dlPFC是一个高级皮层中心，在特定的环境或情绪背景下，不确定性管理、运动促进和心血管控制过程相互交织并整合在一起，以产生最佳的行为反应。本文提供了该领域的最新进展总结，以加速新兴神经调节技术的发展，用于为老年人群中的情绪、睡眠和认知障碍患者进行脑刺激和记录。
