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[钙拮抗剂治疗动脉高血压]

[Treatment of arterial hypertension with calcium antagonists].

作者信息

Gurgenian S V, Tatinian N G, Mikaelian E S, Grigorian T Z, Nikogosian K G

出版信息

Kardiologiia. 1985 Jan;25(1):38-41.

PMID:3981859
Abstract

The antihypertensive effect of finoptin (verapamil) and corinfar (nifedipin) and their impact on the hemodynamics and the repolarization complex of the ECG were studied in 52 patients with essential hypertension and 48 patients with secondary arterial hypertension. The calcium antagonists were found to effectively decrease the blood pressure by reducing the peripheral resistance. Verapamil may be recommended for the monotherapy of mild and moderate forms of arterial hypertension, whereas corinfar should be used in cases of marked hypertension and at the third stage of therapy. Patients with electrocardiographic signs of myocardial ischemia show the normalization of the ST segment and a decreased depression of T wave under the impact of corinfar.

摘要

对52例原发性高血压患者和48例继发性高血压患者研究了异搏定(维拉帕米)和硝苯地平的降压作用及其对血流动力学和心电图复极复合体的影响。发现钙拮抗剂可通过降低外周阻力有效降低血压。维拉帕米可推荐用于轻、中度动脉高血压的单一疗法,而硝苯地平应用于重度高血压和治疗第三阶段的病例。有心肌缺血心电图征象的患者在硝苯地平的作用下ST段恢复正常,T波压低减轻。

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