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对带状疱疹活疫苗接种后严重不良事件发生过程中病理机制的见解。

Insights into pathologic mechanisms occurring during serious adverse events following live zoster vaccination.

作者信息

Kennedy Peter G E, Grose Charles

机构信息

1School of Psychology and Neuroscience, College of Medical, Veterinary & Life Sciences, Garscube Campus, University of Glasgow, Glasgow, Scotland, United Kingdom.

Division of Infectious Diseases, Virology Laboratory, Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA.

出版信息

J Virol. 2025 Feb 25;99(2):e0181624. doi: 10.1128/jvi.01816-24. Epub 2025 Jan 17.

DOI:10.1128/jvi.01816-24
PMID:39818965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11852805/
Abstract

An effective live zoster vaccine has been widely used around the world. Although no deaths occurred in the original large clinical trial, we analyzed 10 serious adverse events, including six deaths that have subsequently occurred in four countries. The goal is to define the viral pathogenesis of these unexpected adverse events secondary to a viremia with dissemination of the vaccine virus. We also propose a new hypothesis for acute retinal necrosis that occurs post-immunization.

摘要

一种有效的带状疱疹活疫苗已在全球广泛使用。尽管在最初的大型临床试验中没有死亡病例发生，但我们分析了10例严重不良事件，包括随后在4个国家发生的6例死亡病例。目的是确定这些继发于疫苗病毒播散性病毒血症的意外不良事件的病毒发病机制。我们还提出了一种关于免疫后发生急性视网膜坏死的新假说。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b62/11852805/f0d58f727635/jvi.01816-24.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b62/11852805/5946eaa4e35b/jvi.01816-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b62/11852805/f0d58f727635/jvi.01816-24.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b62/11852805/5946eaa4e35b/jvi.01816-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b62/11852805/f0d58f727635/jvi.01816-24.f002.jpg

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J Clin Immunol. 2024 Jan 26;44(2):56. doi: 10.1007/s10875-024-01653-5.
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Front Pediatr. 2025 Apr 16;13:1567164. doi: 10.3389/fped.2025.1567164. eCollection 2025.
The Spectrum of Neurological Manifestations of Varicella-Zoster Virus Reactivation.
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