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苯丙胺类兴奋剂使用障碍药物治疗的局限性与未来方向

Limitations and Future Directions in Pharmacological Treatment for Amphetamine-Type Stimulant Use Disorder.

作者信息

Bahji Anees

机构信息

Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

出版信息

Can J Psychiatry. 2025 Feb;70(2):136-137. doi: 10.1177/07067437241312683. Epub 2025 Jan 17.

DOI:10.1177/07067437241312683
PMID:39819145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11748372/
Abstract

Plain Language Summary Stimulant addiction, such as addiction to drugs like amphetamines, is a growing public health concern, but there are very few effective medications to treat it. A recent study reviewed a drug called modafinil and found it didn't help reduce drug use, cravings, or improve treatment outcomes. This article discusses why treatments that work for other addictions, like opioids, are less effective for stimulants. It also highlights the challenges researchers face, such as differences in study methods and overlooking common issues like mental health problems or using multiple substances. The focus on complete abstinence as a treatment goal is another issue. Harm reduction, which involves reducing drug use and improving health and social well-being, could be more realistic and beneficial for many people. Finally, while therapy remains the most effective treatment, it's not always accessible. This article calls for new, innovative approaches that prioritize harm reduction, safety, and long-term recovery.

摘要

通俗易懂的总结 兴奋剂成瘾,如苯丙胺类药物成瘾,是一个日益严重的公共卫生问题,但治疗该问题的有效药物却非常少。最近一项研究评估了一种名为莫达非尼的药物,发现它无助于减少药物使用、减轻渴望或改善治疗效果。本文讨论了为何对其他成瘾(如阿片类药物成瘾)有效的治疗方法对兴奋剂成瘾效果较差。它还强调了研究人员面临的挑战,如研究方法的差异以及忽视心理健康问题或使用多种物质等常见问题。将完全戒断作为治疗目标也是一个问题。减少伤害,即减少药物使用并改善健康和社会福祉,对许多人来说可能更现实且有益。最后,虽然心理治疗仍然是最有效的治疗方法,但并非总是能够获得。本文呼吁采取新的创新方法,将减少伤害、安全和长期康复作为优先事项。

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本文引用的文献

1
Efficacy and Safety of Modafinil for Treatment of Amphetamine-Type Stimulant Use Disorder: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials: Efficacité et innocuité du modafinil pour le traitement des troubles liés à l'usage de stimulants de type amphétamine : revue systématique et méta-analyse d'essais randomisés contrôlés par placebo.莫达非尼治疗苯丙胺类兴奋剂使用障碍的疗效和安全性:随机安慰剂对照试验的系统评价和荟萃分析:莫达非尼治疗苯丙胺类兴奋剂使用障碍的疗效和安全性:随机安慰剂对照试验的系统评价和荟萃分析。
Can J Psychiatry. 2024 Nov;69(11):793-805. doi: 10.1177/07067437241262967. Epub 2024 Jul 21.
2
The Rising Tide of Stimulant-Related Morbidity and Mortality Warrants Evidence-Based Treatment.兴奋剂相关发病率和死亡率的上升趋势需要循证治疗。
Can J Psychiatry. 2023 Mar;68(3):208-209. doi: 10.1177/07067437221125301. Epub 2022 Sep 15.
3
Responding to global stimulant use: challenges and opportunities.应对全球兴奋剂使用问题:挑战与机遇。
Lancet. 2019 Nov 2;394(10209):1652-1667. doi: 10.1016/S0140-6736(19)32230-5. Epub 2019 Oct 23.
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Efficacy and safety of psychostimulants for amphetamine and methamphetamine use disorders: a systematic review and meta-analysis.精神兴奋剂用于苯丙胺和甲基苯丙胺使用障碍的疗效与安全性:一项系统评价和荟萃分析
Syst Rev. 2016 Nov 14;5(1):189. doi: 10.1186/s13643-016-0370-x.
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Characteristics of homeless youth who use cocaine and methamphetamine.无家可归的青少年使用可卡因和冰毒的特征。
Am J Addict. 2012 May-Jun;21(3):243-9. doi: 10.1111/j.1521-0391.2012.00233.x.