Lee Seung-Hoon, Hyung Won Seok William, Seo Surin, Kim Junhyung, Han Changsu, Choi Kwang-Yeon, Youn HyunChul, Jeong Hyun-Ghang
Department of Psychiatry, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Korea University Research Institute of Mental Health, Seoul, Korea.
Clin Psychopharmacol Neurosci. 2025 Feb 28;23(1):65-75. doi: 10.9758/cpn.24.1181. Epub 2024 Jun 4.
: Multiple cohort studies have investigated the potential link between anesthesia and dementia. However, mixed findings necessitate closer examination. This study aimed to investigate the association between anesthesia exposure and the incidence of dementia, considering different anesthesia types and anesthetic agents.
: This nationwide cohort study utilized data from the South Korean Health Insurance Review and Assessment Service database, covering 62,541 participants, to investigate the correlation between anesthesia exposure and dementia incidence.
: Results revealed an increased risk of dementia in individuals who underwent general (hazard ratio [HR], 1.318; 95% confidence interval [CI], 1.061-1.637) or regional/local anesthesia (HR, 2.097; 95% CI, 1.887-2.329) compared to those who did not. However, combined general and regional/local anesthesia did not significantly increase dementia risk (HR, 1.097; 95% CI, 0.937-1.284). Notably, individual anesthetic agents exhibited varying risks; desflurane and midazolam showed increased risks, whereas propofol showed no significant difference.
: This study provides unique insights into the nuanced relationship between anesthesia, individual anesthetic agents, and the incidence of dementia. While confirming a general association between anesthesia exposure and dementia risk, this study also emphasizes the importance of considering specific agents. These findings under-score the need for careful evaluation and long-term cognitive monitoring after anesthesia.
多项队列研究调查了麻醉与痴呆之间的潜在联系。然而，研究结果不一，需要进一步仔细研究。本研究旨在探讨麻醉暴露与痴呆发病率之间的关联，同时考虑不同的麻醉类型和麻醉剂。
这项全国性队列研究利用了韩国健康保险审查和评估服务数据库中的数据，涵盖62541名参与者，以调查麻醉暴露与痴呆发病率之间的相关性。
结果显示，与未接受麻醉的个体相比，接受全身麻醉（风险比[HR]，1.318；95%置信区间[CI]，1.061-1.637）或区域/局部麻醉（HR，2.097；95%CI，1.887-2.329）的个体患痴呆的风险增加。然而，全身麻醉与区域/局部麻醉联合使用并未显著增加痴呆风险（HR，1.097；95%CI，0.937-1.284）。值得注意的是，不同的麻醉剂显示出不同的风险；地氟烷和咪达唑仑显示风险增加，而丙泊酚则无显著差异。
本研究为麻醉、个体麻醉剂与痴呆发病率之间的细微关系提供了独特见解。在证实麻醉暴露与痴呆风险之间存在普遍关联的同时，本研究还强调了考虑特定麻醉剂的重要性。这些发现强调了麻醉后进行仔细评估和长期认知监测的必要性。
