Bagali Kiran Basawaraj, Pathak Harsh, Nayok Swarna Buddha, Balachander Srinivas, Sreeraj Vanteemar S, Venkatasubramanian Ganesan
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.
Department of Clinical Neurosciences, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.
Clin Psychopharmacol Neurosci. 2025 Feb 28;23(1):171-174. doi: 10.9758/cpn.24.1198. Epub 2024 Oct 21.
Auditory/visual hallucinations and perceptual anomalies are one of the core symptoms experienced by patients with schizophrenia. Studies have implicated lateral occipital cortex (LOC) as one of the areas to be aberrantly functioning in schizophrenia, possibly associated with the auditory/visual symptoms of schizophrenia. Here we report of a case of a 29-year-old female diagnosed with treatment resistant schizophrenia on clozapine with persistent auditory verbal hallucinations (AVH) and visual anomalies. Upon targeting the LOC (-40, -66, -8) in this patient, there was a > 25% reduction in AVH, with reduction in the frequency of most visual anomalies and an overall significant response in terms of reduction of symptoms and improvement in functioning. We further discuss the potential of LOC as a novel target for neuromodulation in patients exhibiting perceptual abnormalities especially in auditory and visual senses.
听觉/视觉幻觉和感知异常是精神分裂症患者经历的核心症状之一。研究表明枕叶外侧皮质（LOC）是精神分裂症中功能异常的区域之一，可能与精神分裂症的听觉/视觉症状有关。在此，我们报告一例29岁女性，诊断为难治性精神分裂症，服用氯氮平，伴有持续性幻听（AVH）和视觉异常。针对该患者的枕叶外侧皮质（-40，-66，-8）进行治疗后，幻听减少了25%以上，大多数视觉异常的频率降低，症状减轻和功能改善方面总体有显著反应。我们进一步讨论了枕叶外侧皮质作为表现出感知异常（尤其是听觉和视觉）患者神经调节新靶点的潜力。
