Xiao Guocheng, Ge Mei, Qiao Guoqing, Liu Shuyu, Li Na, Liu Feng, Lu Yanye, Ren Qiushi, Wang Liqiang
Medical School of Chinese People's Liberation Army, Beijing, China.
Department of Ophthalmology, the First Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China.
Transl Vis Sci Technol. 2025 Jan 2;14(1):18. doi: 10.1167/tvst.14.1.18.
The purpose of this study was to evaluate the correlation between axial length (AL) and retinal oxygen dynamic parameters in adult patients.
This was an observational cross-sectional study with 79 Chinese adults with myopia aged 18 to 37 years. All participants underwent AL measurements, cycloplegic refraction, and other ophthalmic examinations. Additionally, the retinal oxygen kinetics imaging and analysis (ROKIA) system was utilized to obtain the retinal oxygen dynamic parameters of all patients. Simple and multiple linear regression tests were used to assess the correlation between various oxygen dynamic parameters and AL.
The mean age, AL, and spherical equivalent (SE) of subjects were 26.32 ± 5.4 years, 25.78 ± 1.06 mm, and -5.13 ± 2.1 diopters (D), respectively. The Pearson correlation coefficients among AL and retinal oxygen delivery (DO2) and retinal oxygen metabolism (MO2) were -0.44 (95% confidence interval = -0.24 to -0.60, P < 0.001), -0.26 (95% confidence interval = -0.04 to -0.46, P = 0.02), respectively. The group with high myopia exhibited lower DO2 and higher oxygen extraction fraction (OEF) compared with the group with moderate myopia, and no significant difference was observed in MO2 between the two groups. In multivariate analyses adjusting for age, sex, intraocular pressure (IOP), and anterior chamber depth (ACD), a longer AL was significantly associated with decreased DO2 (standardized regression coefficient B = -0.47, P < 0.001).
Retinal oxygen dynamic parameters, including DO2 and MO2, were decreased with longer AL in myopic eyes. Patients with high myopia demonstrated an elevated OEF than those with moderate myopia.
This study demonstrated that the retinal oxygen metabolism changes in myopia, as confirmed using a novel device that quantifies retinal oxygen dynamic parameters and provides a new monitoring approach for other hypoxic retinal diseases.
本研究旨在评估成年患者眼轴长度（AL）与视网膜氧动力学参数之间的相关性。
这是一项观察性横断面研究，纳入了79名年龄在18至37岁之间的中国成年近视患者。所有参与者均接受了眼轴长度测量、散瞳验光及其他眼科检查。此外，使用视网膜氧动力学成像与分析（ROKIA）系统获取所有患者的视网膜氧动力学参数。采用简单和多元线性回归检验来评估各种氧动力学参数与眼轴长度之间的相关性。
受试者的平均年龄、眼轴长度和等效球镜度（SE）分别为26.32±5.4岁、25.78±1.06毫米和-5.13±2.1屈光度（D）。眼轴长度与视网膜氧输送（DO2）和视网膜氧代谢（MO2）之间的Pearson相关系数分别为-0.44（95%置信区间=-0.24至-0.60，P<0.001）、-0.26（95%置信区间=-0.04至-0.46，P=0.02）。与中度近视组相比，高度近视组的DO2较低，氧摄取分数（OEF）较高，两组之间的MO2无显著差异。在对年龄、性别、眼压（IOP）和前房深度（ACD）进行校正的多因素分析中，较长的眼轴长度与DO2降低显著相关（标准化回归系数B=-0.47，P<0.001）。
近视眼中，包括DO2和MO2在内的视网膜氧动力学参数随眼轴长度增加而降低。高度近视患者的OEF高于中度近视患者。
本研究表明近视患者视网膜氧代谢发生变化，这一结果通过一种能够量化视网膜氧动力学参数的新型设备得到证实，为其他缺氧性视网膜疾病提供了一种新的监测方法。
