State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
Invest Ophthalmol Vis Sci. 2024 Aug 1;65(10):7. doi: 10.1167/iovs.65.10.7.
To examine the influence of subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) on axial length (AL) elongation over a 2-year period in highly myopic children.
In this is prospective, longitudinal, observational study, 163 participants (74%), who were 8 to 18 years of age with bilateral high myopia (sphere ≤ -6.0 D) and without pathologic myopia, completed follow-up visits over 2 years. All participants underwent baseline and follow-up ocular examinations, including swept-source optical coherence tomography (SS-OCT) and AL measurements. SFCT and CVI were derived from SS-OCT scans using a deep-learning-based program for choroidal structure assessment.
The mean age of the participants at baseline was 15.0 years (±2.3), with males constituting 47% of the cohort. An inverse relationship was observed between AL elongation and increases in baseline age, baseline SFCT, and CVI, as well as a decrease in baseline AL. Adjusting for other factors, every 10-µm increase in SFCT and each 1% increase in CVI were associated with decreases in AL elongation of 0.007 mm (95% confidence interval [CI], -0.013 to -0.002; P = 0.011) and 0.010 mm (95% CI, -0.019 to 0.000; P = 0.050), respectively. The incorporation of SFCT or CVI into predictive models improved discrimination over models using only age, gender, and baseline AL (both P < 0.05, likelihood ratio test).
Our findings suggest a possible association between a thinner choroid and increased AL elongation over 2 years in children with high myopia, after adjusting for potential baseline risk factors such as age, gender, and initial AL.
研究在 2 年内，脉络膜厚度（SFCT）和脉络膜血管指数（CVI）对高度近视儿童眼轴（AL）延长的影响。
本前瞻性、纵向、观察性研究纳入了 163 名（74%）年龄在 8 至 18 岁、双眼高度近视（球镜度≤-6.0D）且无病理性近视的患者。所有患者均完成了 2 年的随访。所有患者均进行了基线和随访眼部检查，包括扫频源光学相干断层扫描（SS-OCT）和 AL 测量。SFCT 和 CVI 由 SS-OCT 扫描通过基于深度学习的脉络膜结构评估程序得出。
患者的平均基线年龄为 15.0 岁（±2.3），男性占队列的 47%。AL 延长与基线年龄、基线 SFCT 和 CVI 增加以及基线 AL 降低呈负相关。在调整其他因素后，SFCT 每增加 10µm 和 CVI 增加 1%，AL 延长减少 0.007mm（95%置信区间[CI]，-0.013 至 -0.002；P=0.011）和 0.010mm（95%CI，-0.019 至 0.000；P=0.050）。将 SFCT 或 CVI 纳入预测模型可提高模型对年龄、性别和基线 AL 等潜在基线危险因素的区分度（均 P<0.05，似然比检验）。
在调整年龄、性别和初始 AL 等潜在基线危险因素后，我们的发现表明脉络膜变薄可能与高度近视儿童 2 年内 AL 延长有关。
