den Heeten G J, Oldhoff J, Oosterhuis J W, Schraffordt Koops H
J Surg Oncol. 1985 Apr;28(4):247-51. doi: 10.1002/jso.2930280402.
Bone biopsy is not only the most important step in the diagnosis of bone tumours, but since the introduction of chemotherapy, it has also become essential in the evaluation of treatment of highly malignant bone tumours. A total of 206 bone biopsies were performed on 136 patients seen between January 1, 1978 and August 1, 1982 (99 open and 107 drill biopsies). Complications during or after biopsy were relatively rare, and none were of a serious nature. Pathological fractures at sites of biopsies developed exclusively in patients given chemotherapy. In gaining adequate histologic material, the overall result of open bone biopsies (98%) was superior to that of drill biopsies (70%). The choice between both techniques was dependent on individual patient factors. Of the total of 206 bone biopsies, 10% proved not to be representative. It is concluded that, especially in patients given chemotherapy for a malignant tumour of a long bone, the possibility of a spontaneous fracture after a bone biopsy should be borne in mind.
骨活检不仅是骨肿瘤诊断中最重要的步骤，而且自化疗引入以来，它在评估高度恶性骨肿瘤的治疗方面也变得至关重要。1978年1月1日至1982年8月1日期间，对136例患者共进行了206次骨活检（99次切开活检和107次钻孔活检）。活检期间或之后的并发症相对较少，且均不严重。活检部位的病理性骨折仅发生在接受化疗的患者中。在获取足够的组织学材料方面，切开骨活检的总体成功率（98%）高于钻孔活检（70%）。两种技术的选择取决于患者的个体因素。在总共206次骨活检中，10%的结果被证明不具有代表性。得出的结论是，特别是对于接受长骨恶性肿瘤化疗的患者，应牢记骨活检后发生自发性骨折的可能性。
