Xin Liu, Kanghao Ning, Jiacheng Li, Xiaodong Yan, Juhan Yan, Xinyang Zhao, Xiangdong Li
The First Affiliated Hospital of Hebei North University Address, 12 Changqing Road, Zhangjiakou City, Hebei Province, China.
Graduate School of Hebei North University, Zhangjiakou, China.
Mol Biotechnol. 2025 Jan 17. doi: 10.1007/s12033-025-01366-z.
Renal ischemia-reperfusion injury (RIRI) is a primary cause of acute kidney injury (AKI), frequently resulting in high mortality rates and progression to chronic kidney disease (CKD). This study aimed to investigate the therapeutic potential of total saponins from Panax notoginseng (PNS) in the context of RIRI. Utilizing a murine RIRI model, the efficacy of PNS was evaluated, demonstrating a significant reduction in renal inflammation and cellular pyroptosis. Furthermore, PNS was found to modulate the ROCK2/NF-κB signaling pathway, thereby attenuating the inflammatory response. Importantly, in vitro experiments with hypoxia/reoxygenation cell models corroborated these findings, showing that PNS inhibited pyroptosis and regulated the ROCK2/NF-κB pathway. This research underscores the therapeutic potential of PNS in the treatment of RIRI, providing a robust scientific basis for its consideration as a prospective clinical therapy.
肾缺血再灌注损伤（RIRI）是急性肾损伤（AKI）的主要原因，常导致高死亡率并进展为慢性肾脏病（CKD）。本研究旨在探讨三七总皂苷（PNS）在RIRI中的治疗潜力。利用小鼠RIRI模型评估了PNS的疗效，结果表明其可显著减轻肾脏炎症和细胞焦亡。此外，发现PNS可调节ROCK2/NF-κB信号通路，从而减轻炎症反应。重要的是，缺氧/复氧细胞模型的体外实验证实了这些发现，表明PNS可抑制焦亡并调节ROCK2/NF-κB通路。本研究强调了PNS在治疗RIRI方面的治疗潜力，为其作为一种潜在的临床治疗方法提供了有力的科学依据。
