Tharmarajah Brindhan, Cornish Elisa E, Nguyen Jonathan, Barnes Elizabeth, Leahy Kate E, Vaze Anagha, Jamieson Robyn V, Grigg John R
Save Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Sydney Eye Hospital, Sydney, NSW, Australia.
Eye (Lond). 2025 Feb;39(3):527-532. doi: 10.1038/s41433-024-03584-2. Epub 2025 Jan 16.
To determine how Hardy-Rand-Rittler (HRR) colour vision testing correlates with visual functional and structural assessments in Cone and Cone-Rod Dystrophy.
Thirty-four Cone and 69 Cone-Rod Dystrophy patients diagnosed by electroretinography (ERG) at the Save Sight Institute in Sydney were included in a retrospective analysis. Each patient's HRR colour vision test scores were compared with markers of cone and rod system function including visual acuity (VA), ERG responses, changes on Spectral Domain Optical Coherence Tomography (OCT) and Fundus Autofluorescence.
The number of plates identified on HRR testing correlated with logMAR best-corrected distance VA; r(101) = -0.49, p < 0.0001. HRR scores correlated with markers of cone and macula function including OCT Ellipsoid Zone Gap Width, Central Macular and Outer Nuclear Layer Thickness, Full Field ERG 30 Hz flicker amplitudes, light adapted 3.0 b-wave amplitudes and Pattern ERG 15- and 30-degree p50 amplitudes.
HRR colour vision testing correlates with structural and functional measures in Cone and Cone-Rod Dystrophy. HRR colour vision testing provides a simple clinic-based option to monitor disease changes in Cone and Cone-Rod Dystrophy patients, especially when ERG testing is not available.
确定哈迪-兰德-里特勒（HRR）色觉测试与视锥细胞及视锥-视杆细胞营养不良患者的视觉功能和结构评估之间的相关性。
对悉尼拯救视力研究所通过视网膜电图（ERG）诊断的34例视锥细胞营养不良患者和69例视锥-视杆细胞营养不良患者进行回顾性分析。将每位患者的HRR色觉测试分数与视锥细胞和视杆细胞系统功能指标进行比较，这些指标包括视力（VA）、ERG反应、光谱域光学相干断层扫描（OCT）变化和眼底自发荧光。
HRR测试中识别出的图版数量与logMAR最佳矫正远视力相关；r(101) = -0.49，p < 0.0001。HRR分数与视锥细胞和黄斑功能指标相关，包括OCT椭圆体带间隙宽度、中心黄斑和外核层厚度、全视野ERG 30Hz闪烁振幅、明适应3.0 b波振幅以及图形ERG 15度和30度p50振幅。
HRR色觉测试与视锥细胞及视锥-视杆细胞营养不良的结构和功能测量相关。HRR色觉测试提供了一种基于临床的简单方法，用于监测视锥细胞及视锥-视杆细胞营养不良患者的疾病变化，尤其是在无法进行ERG测试时。
