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A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy.

出版信息

Nat Immunol. 2025 Feb;26(2):170-171. doi: 10.1038/s41590-024-02049-8.

DOI:10.1038/s41590-024-02049-8
PMID:39821150
Abstract
摘要

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A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy.

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引用本文的文献

[1]
Inhibitory leukocyte immunoglobulin-like receptors, subfamily B (LILRBs) in human diseases: structure, roles, mechanisms, and clinical applications.

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[2]
Tumor Immunotherapy Targeting B7-H3: From Mechanisms to Clinical Applications.

Immunotargets Ther. 2025-3-27

本文引用的文献

[1]
Tumor burden, inflammation, and product attributes determine outcomes of axicabtagene ciloleucel in large B-cell lymphoma.

Blood Adv. 2020-10-13

[2]
Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies.

Cancer Cell. 2020-6-8

[3]
Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma.

N Engl J Med. 2017-12-28

[4]
Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15.

Blood. 2014-4-29

[5]
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells.

J Clin Invest. 2005-6

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