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高压氧治疗方案、治疗疾病及不良反应概况:一项水下与高压氧医学协会调查研究

Hyperbaric Oxygen Therapy Regimens, Treated Conditions, and Adverse Effect Profile: an Undersea and Hyperbaric Medical Society Survey Study.

作者信息

Laspro Matteo, Wei Lucy W, Brydges Hilliard T, Gorenstein Scott A, Huang Enoch T, Chiu Ernest S

机构信息

Hansjorg Wyss Department of Plastic Surgery, NYU Grossman School of Medicine, New York, NY.

SUNY Downstate Medical School, Downstate Medical Center, New York, NY.

出版信息

Undersea Hyperb Med. 2024 Fourth Quarter;51(4):369-376.

PMID:39821765
Abstract

INTRODUCTION

When administering HBO , pressures can range from 1.4 atmospheres absolute (ATA) to 3 ATA. While different treatment profiles have been proposed, there is a paucity of literature comparing the effectiveness and risk profile associated with different pressures treating the same condition. Considering the therapeutic divergence, this study aims to survey Undersea and Hyperbaric Medical Society (UHMS) members on pressure modalities and their use in different clinical conditions.

METHODS

The study was a voluntary cross-sectional survey administered online and open to healthcare providers who were Undersea and Hyperbaric Medical Society members. UHMS itself distributed the survey link. The survey period lasted from November 2022 until January 2023. Data were collected utilizing the Qualtrics platform and analyzed through Microsoft Excel.

RESULTS

A total of 265 responses were recorded. The majority responded with utilizing 2.4 ATA (35.2%) as the pressure of choice, followed by 2.0 ATA only (27.1%), and those who utilized differing therapeutic pressures (26.4%). The overwhelming choice for treatment of osteoradionecrosis (ORN) of the jaw, radiation proctitis/cystitis, diabetic foot ulcer, and chronic osteomyelitis was 2.0 ATA (68.0- 74.9%). Among listed adverse effects, myopia was the most commonly reported complication at 24.4%, followed by barotrauma (14.9%) and confinement anxiety (11.5%).

CONCLUSIONS

There is currently little consensus regarding the best treatment modalities for conditions treated with HBO. As adverse effects appear non-negligible, future prospective studies must be conducted weighing the risks and benefits of higher-pressure therapies compared to safer lower-pressure options.

摘要

引言

在进行高压氧治疗(HBO)时,压力范围可从绝对1.4个大气压(ATA)至3个ATA。虽然已经提出了不同的治疗方案,但比较针对相同病症采用不同压力治疗的有效性和风险状况的文献却很少。鉴于治疗方法的差异,本研究旨在对水下和高压氧医学协会(UHMS)成员就压力模式及其在不同临床病症中的应用进行调查。

方法

该研究是一项在线自愿横断面调查,面向水下和高压氧医学协会成员中的医疗服务提供者开放。UHMS本身分发了调查链接。调查期从2022年11月持续至2023年1月。数据通过Qualtrics平台收集,并通过Microsoft Excel进行分析。

结果

共记录到265份回复。大多数人选择2.4 ATA(35.2%)作为首选压力,其次是仅选择2.0 ATA的人(27.1%),以及采用不同治疗压力的人(26.4%)。治疗颌骨放射性骨坏死(ORN)、放射性直肠炎/膀胱炎、糖尿病足溃疡和慢性骨髓炎的压倒性选择是2.0 ATA(68.0 - 74.9%)。在列出的不良反应中,近视是最常报告的并发症,为24.4%,其次是气压伤(14.9%)和幽闭焦虑(11.5%)。

结论

目前对于高压氧治疗的病症,最佳治疗方式几乎没有共识。由于不良反应似乎不可忽视,未来必须进行前瞻性研究,权衡与更安全的低压治疗方案相比,高压治疗的风险和益处。

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