Mohamed Adham H, Abaza Tasneem, Youssef Yomna A, Rady Mona, Fahmy Sherif Ashraf, Kamel Rabab, Hamdi Nabila, Efthimiado Eleni, Braoudaki Maria, Youness Rana A
Department of Chemistry, Faculty of Science, Cairo University 12613 Giza Egypt.
Biotechnology and Biomolecular Chemistry Program, Faculty of Science, Cairo University 12613 Giza Egypt.
Nanoscale Adv. 2025 Jan 15;7(4):934-962. doi: 10.1039/d4na00393d. eCollection 2025 Feb 11.
Extracellular vesicles (EVs) are emerging as viable tools in cancer treatment due to their ability to carry a wide range of theranostic activities. This review summarizes different forms of EVs such as exosomes, microvesicles, apoptotic bodies, and oncosomes. It also sheds the light onto isolation methodologies, characterization techniques and therapeutic applications of all discussed EVs. Evidence indicates that EVs are particularly effective in delivering chemotherapeutic medications, and immunomodulatory agents. However, the advancement of EV-based therapies into clinical practice is hindered by challenges including EVs heterogeneity, cargo loading efficiency, and stability. Overall, EVs have the potential to change cancer therapeutic paradigms. Continued research and development activities are critical for improving EV-based medications and increasing their therapeutic impact.
细胞外囊泡（EVs）因其具有广泛的治疗诊断活性，正逐渐成为癌症治疗中可行的工具。本综述总结了不同形式的细胞外囊泡，如外泌体、微囊泡、凋亡小体和肿瘤小体。它还阐述了所有讨论的细胞外囊泡的分离方法、表征技术和治疗应用。有证据表明，细胞外囊泡在递送化疗药物和免疫调节药物方面特别有效。然而，基于细胞外囊泡的疗法在临床实践中的进展受到诸多挑战的阻碍，包括细胞外囊泡的异质性、货物装载效率和稳定性。总体而言，细胞外囊泡有潜力改变癌症治疗模式。持续的研发活动对于改进基于细胞外囊泡的药物并增强其治疗效果至关重要。
