Molecular Genetics Research Team (MGRT), Molecular Biology and Biochemistry Department, Faculty of Biotechnology, German International University (GIU), Cairo 11835, Egypt.
Biotechnology Program, Institute of Basic and Applied Sciences (BAS), Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab City 21934, Egypt.
Cells. 2024 Jul 24;13(15):1245. doi: 10.3390/cells13151245.
Circular RNAs (circRNAs) are cardinal players in numerous physiological and pathological processes. CircRNAs play dual roles as tumor suppressors and oncogenes in different oncological contexts, including hepatocellular carcinoma (HCC). Their roles significantly impact the disease at all stages, including initiation, development, progression, invasion, and metastasis, in addition to the response to treatment. In this review, we discuss the biogenesis and regulatory functional roles of circRNAs, as well as circRNA-protein-mRNA ternary complex formation, elucidating the intricate pathways tuned by circRNAs to modulate gene expression and cellular processes through a comprehensive literature search, in silico search, and bioinformatics analysis. With a particular focus on the interplay between circRNAs, epigenetics, and HCC pathology, the article sets the stage for further exploration of circRNAs as novel investigational theranostic agents in the dynamic realm of HCC.
环状 RNA（circRNAs）是许多生理和病理过程中的关键参与者。circRNAs 在不同的肿瘤学背景下发挥着肿瘤抑制因子和癌基因的双重作用，包括肝细胞癌（HCC）。它们的作用在疾病的各个阶段都有显著影响，包括起始、发展、进展、侵袭和转移，以及对治疗的反应。在这篇综述中，我们讨论了 circRNAs 的生物发生和调节功能作用，以及 circRNA-蛋白-mRNA 三元复合物的形成，通过全面的文献检索、计算机检索和生物信息学分析，阐明了 circRNAs 调节基因表达和细胞过程的复杂途径。特别关注 circRNAs、表观遗传学和 HCC 病理学之间的相互作用，本文为进一步探索 circRNAs 作为 HCC 动态领域中新型研究治疗剂奠定了基础。
