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通过荷兰市政登记处为叙利亚移民提供乙型和丙型肝炎即时检测服务。

Reaching Syrian migrants through Dutch municipal registries for hepatitis B and C point-of-care testing.

作者信息

Moonen Chrissy P B, Brouwers Elfi E H G, Hoebe Christian J P A, Dukers-Muijrers Nicole H T M, Bouchaara Jamila, van Loo Inge H M, den Heijer Casper D J

机构信息

Department of Sexual Health, Infectious Diseases and Environmental Health, Living Lab Public Health, South Limburg Public Health Service, Heerlen, The Netherlands.

Department of Social Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.

出版信息

PLoS One. 2025 Jan 17;20(1):e0316726. doi: 10.1371/journal.pone.0316726. eCollection 2025.

Abstract

Undetected chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections can lead to cirrhosis and liver cancer. Syrian migrants are the largest non-European migrant group in the Netherlands with HBV and HCV prevalence rates above 2%. This study aimed to reach Syrian migrants for HBV and HCV testing using point-of-care tests (POCT). A multifaceted strategy was employed to reach Syrian migrants aged ≥16 years from two Dutch municipalities for free-of-charge HBsAg and anti-HCV POCT using finger prick blood at the regional Public Health Service. All were personally invited by the Public Health Service by postal mail, based on municipal registry data. Respondents' medical history data were analysed descriptively and data on age, sex, and municipality were compared with non-participating invitees, using Pearson's Chi-square test. Of the study population (N = 832), 32.3% (n = 269) attended the testing. The mean age of participants was 36 years (range 16-70), 59.1% were men, and 66.5% were unemployed. Non-participation was higher in the younger age groups (<30 years) (p < .001). The POCT using finger prick blood was well received. None tested HBsAg or anti-HCV positive. With approximately one-third of participation, this study demonstrated relatively high reach of Syrian migrants for testing, compared to studies with similar recruitment methods. However, while the reach could be considered successful, testing failed to demonstrate new infection in this key population. Thereby, other methods may be preferred to identify new HBV and HCV infections, such as opportunistic testing within existing care processes.

摘要

未被检测出的慢性乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)感染可导致肝硬化和肝癌。叙利亚移民是荷兰最大的非欧洲移民群体,其HBV和HCV患病率高于2%。本研究旨在使用即时检验(POCT)对叙利亚移民进行HBV和HCV检测。采用多方面策略,在荷兰两个市镇针对年龄≥16岁的叙利亚移民,在地区公共卫生服务机构通过手指采血免费进行HBsAg和抗HCV POCT检测。根据市镇登记数据,公共卫生服务机构通过邮政邮件亲自邀请所有人。对受访者的病史数据进行描述性分析,并使用Pearson卡方检验将年龄、性别和市镇数据与未参与邀请者进行比较。在研究人群(N = 832)中,32.3%(n = 269)参加了检测。参与者的平均年龄为36岁(范围16 - 70岁),59.1%为男性,66.5%失业。较年轻年龄组(<30岁)的未参与率更高(p <.001)。手指采血的POCT检测受到广泛接受。没有人检测出HBsAg或抗HCV呈阳性。与采用类似招募方法的研究相比,本研究约三分之一的参与率表明对叙利亚移民的检测覆盖面相对较高。然而,虽然覆盖面可被视为成功,但检测未能在这一关键人群中发现新的感染情况。因此,可能更倾向于采用其他方法来识别新的HBV和HCV感染,例如在现有医疗过程中进行机会性检测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17f3/11741604/d903f57b144e/pone.0316726.g001.jpg

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