Yuan Menghan, Zhang Yingyue, Zuo Nina, Lei Haoying, Zhao Xuming, Xu Yong
Medical School of Chinese PLA.
Senior Department of Cardiology, the Sixth Medical Center of PLA General Hospital, Beijing, China.
J Hypertens. 2025 Mar 1;43(3):492-503. doi: 10.1097/HJH.0000000000003931. Epub 2024 Nov 20.
The oxidative balance score (OBS) has emerged as a novel marker for assessing oxidative stress status. This study aimed to investigate the association of OBS with systolic blood pressure (SBP), diastolic blood pressure (DBP), all-cause, and cardiovascular disease mortality in hypertensive patients.
We conducted an analysis of data from 7602 hypertensive patients from the National Health and Nutrition Examination Survey (NHANES) 2005-2018. Multiple linear regression, Cox proportional hazards models, Kaplan-Meier survival curves, restricted cubic spline, and subgroup analysis were used to examine the association between OBS and SBP, DBP, estimated pulse wave velocity (ePWV), and mortality risk.
The results showed that individuals in the highest OBS quartile (27 ≤ OBS ≤ 40) had a significant 2.41 mmHg reduction in SBP compared to the lowest quartile (5 ≤ OBS ≤ 15) ( Ptrend < 0.001). Compared to the lowest quartile, individuals in the highest OBS quartile had a 29% lower risk of all-cause mortality and a 44% lower risk of cardiovascular disease mortality ( Ptrend < 0.001). This inverse association persisted irrespective of antihypertensive medication use. OBS is inversely associated with SBP, all-cause, and cardiovascular disease mortality in hypertensive patients.
This finding provides new evidence and suggestions for those with poor blood pressure control and low OBS (<15) to adjust their diet and lifestyle reasonably.
氧化平衡评分（OBS）已成为评估氧化应激状态的一种新标志物。本研究旨在探讨OBS与高血压患者收缩压（SBP）、舒张压（DBP）、全因死亡率和心血管疾病死亡率之间的关联。
我们对2005 - 2018年美国国家健康与营养检查调查（NHANES）中7602例高血压患者的数据进行了分析。采用多元线性回归、Cox比例风险模型、Kaplan - Meier生存曲线、受限立方样条和亚组分析来检验OBS与SBP、DBP、估计脉搏波速度（ePWV）和死亡风险之间的关联。
结果显示，与最低四分位数（5≤OBS≤15）相比，OBS最高四分位数（27≤OBS≤40）的个体SBP显著降低2.41 mmHg（Ptrend＜0.001）。与最低四分位数相比，OBS最高四分位数的个体全因死亡率风险降低29%，心血管疾病死亡率风险降低44%（Ptrend＜0.001）。无论是否使用抗高血压药物，这种负相关关系均持续存在。OBS与高血压患者的SBP、全因死亡率和心血管疾病死亡率呈负相关。
这一发现为血压控制不佳且OBS较低（＜15）的患者合理调整饮食和生活方式提供了新的证据和建议。
