Zhao Wei, Sun Yiyuan, Zhu Bohui
Department of Oncology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, China.
Sci Rep. 2025 Jan 31;15(1):3901. doi: 10.1038/s41598-025-87996-4.
Asthma poses significant societal costs, and a wholesome diet coupled with an energetic lifestyle might enhance postpartum results. Regrettably, empirical investigations into dietary and lifestyle aspects that amplify asthma risk remain scarce. The oxidative balance scores (OBS), quantifying oxidative stress from dietary elements and lifestyle parameters, lack a definitive link to overall and cardiovascular mortality among asthmatic individuals. Data sourced from NHANES (1999-2020) were utilized to investigate the correlation between the OBS index and all-cause and cardiovascular mortality among asthmatic patients. Rigor was maintained through the implementation of subgroup and sensitivity analyses to authenticate the findings. The study finally included 4,639 individuals with a mean age of 42.55 years and 43.46% males. Kaplan-Meier curves showed that asthmatics with lower OBS quartiles had a higher risk of all-cause and cardiovascular mortality. In the fully adjusted Model 2, the HR for all-cause mortality in the upper quartile of asthmatics in the OBS was 0.37 (95% CI: 0.26, 0.53), in contrast to the lower quartile of asthmatics. Cardiovascular disease mortality showed consistency (Q4, HR: 0.43, 95% CI: 0.19, 0.98). The association between the OBS index and both all-cause and cardiovascular mortality in asthma patients remained stable across different models and subgroup assessments. Restricted cubic spline curves showed that OBS was linearly associated with all-cause and cardiovascular mortality in asthmatics. A sensitivity analysis reinforced the negative correlation between the OBS index and mortality in asthma patients. The OBS index was negatively correlated with all-cause and cardiovascular mortality in patients with asthma, emphasizing the protective effect of an antioxidant diet and a healthy lifestyle in patients with asthma.
哮喘造成了巨大的社会成本，而健康的饮食加上积极的生活方式可能会改善产后结果。遗憾的是，关于增加哮喘风险的饮食和生活方式因素的实证研究仍然很少。氧化平衡评分（OBS）用于量化饮食元素和生活方式参数产生的氧化应激，但与哮喘患者的全因死亡率和心血管死亡率之间缺乏明确的联系。本研究利用来自美国国家健康与营养检查调查（NHANES，1999 - 2020）的数据，调查OBS指数与哮喘患者全因死亡率和心血管死亡率之间的相关性。通过进行亚组分析和敏感性分析来验证研究结果，以确保研究的严谨性。该研究最终纳入了4639名个体，平均年龄为42.55岁，男性占43.46%。卡普兰 - 迈耶曲线显示，OBS四分位数较低的哮喘患者全因死亡率和心血管死亡率风险更高。在完全调整的模型2中，OBS处于上四分位数的哮喘患者全因死亡率的风险比（HR）为0.37（95%置信区间：0.26，0.53），而处于下四分位数的哮喘患者则相反。心血管疾病死亡率呈现出一致性（第四四分位数，HR：0.43，95%置信区间：0.19，0.98）。在不同模型和亚组评估中，OBS指数与哮喘患者全因死亡率和心血管死亡率之间的关联保持稳定。受限立方样条曲线显示，OBS与哮喘患者全因死亡率和心血管死亡率呈线性相关。敏感性分析进一步强化了OBS指数与哮喘患者死亡率之间的负相关关系。OBS指数与哮喘患者全因死亡率和心血管死亡率呈负相关，强调了抗氧化饮食和健康生活方式对哮喘患者的保护作用。
