从一位患有长期新冠的患者身上生成诱导多能干细胞系。
Generation of induced pluripotent stem cell line from a patient with long COVID.
作者信息
Wu David, Manhas Amit, Noishiki Chikage, Tripathi Dipti, Liu Lu, Turbes Naima, Thomas Dilip, Sallam Karim, Lee Jason T, Sayed Nazish
机构信息
Stanford Cardiovascular Institute, Stanford University School of Medicine, CA, USA; Division of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, CA, USA.
Stanford Cardiovascular Institute, Stanford University School of Medicine, CA, USA; Baszucki Family Vascular Surgery Biobank, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, CA, USA.
出版信息
Stem Cell Res. 2025 Mar;83:103652. doi: 10.1016/j.scr.2025.103652. Epub 2025 Jan 4.
Long COVID, or post-acute sequelae of SARS-CoV-2 infection, leads to vascular dysfunction, which contributes to the chronic multi-organ damage often seen in affected patients. Long COVID, a global health concern is associated with increased thrombotic risk, also known as COVID-19-associated coagulopathy (CAC). Here, we derived an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMCs) of a long COVID patient. This iPSC line showed normal morphology, maintained pluripotency, had a stable karyotype, and demonstrated the ability to differentiate into the three germ layers (ectoderm, endoderm, and mesoderm). This line provides a valuable tool for modeling long COVID and exploring mechanisms underlying multi-organ dysfunction.
长新冠，即新冠病毒感染后的急性后遗症，会导致血管功能障碍，这是造成受影响患者常见慢性多器官损伤的原因。长新冠是一个全球健康问题，与血栓形成风险增加有关，也称为新冠相关凝血病（CAC）。在此，我们从一名长新冠患者的外周血单个核细胞（PBMC）中获得了诱导多能干细胞（iPSC）系。该iPSC系形态正常，保持多能性，具有稳定的核型，并表现出分化为三个胚层（外胚层、内胚层和中胚层）的能力。该细胞系为模拟长新冠和探索多器官功能障碍的潜在机制提供了一个有价值的工具。
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