Cai Jiaer, Liao Wei, Wen Jiahui, Ye Fangting, Nie Qing, Chen Weichao, Zhao Chao
College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Int J Biol Macromol. 2025 Mar;297:139936. doi: 10.1016/j.ijbiomac.2025.139936. Epub 2025 Jan 15.
Breast cancer is the second leading cause of cancer-related mortality among women worldwide, with its progression closely tied to the tumor microenvironment. To address the limitations and adverse effects of conventional therapies, algal polysaccharides and their nanoparticle derivatives have emerged as promising and effective anti-breast cancer agents. These bioactive compounds, derived from algae, are distinguished by their natural origin, non-toxicity, and significant medical relevance. Notably, algal polysaccharide-based nanoparticles exhibit advantageous properties such as hydrophilicity, biodegradability, prolonged circulation, and selective accumulation in tumor tissues. This review explores the relationship between the structural attributes of algal polysaccharides and their therapeutic efficacy. It further highlights the advantages of algal polysaccharide-based nanoparticles as drug delivery systems, particularly their potential in tumor targeting and overcoming multidrug resistance, thereby providing a theoretical foundation for their application in breast cancer treatment.
乳腺癌是全球女性癌症相关死亡的第二大主要原因，其进展与肿瘤微环境密切相关。为了克服传统疗法的局限性和不良反应，藻类多糖及其纳米颗粒衍生物已成为有前景的有效抗乳腺癌药物。这些源自藻类的生物活性化合物以其天然来源、无毒性和显著的医学相关性而著称。值得注意的是，基于藻类多糖的纳米颗粒具有亲水性、可生物降解性、循环时间延长以及在肿瘤组织中选择性积累等优势特性。本文综述探讨了藻类多糖的结构属性与其治疗效果之间的关系。它进一步强调了基于藻类多糖的纳米颗粒作为药物递送系统的优势，特别是其在肿瘤靶向和克服多药耐药性方面的潜力，从而为其在乳腺癌治疗中的应用提供理论基础。
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