Chakraborty Debarupa Dutta, Chakraborty Prithviraj, Mondal Arijit
Royal School of Pharmacy, The Assam Royal Global University, Betkuchi, Guwahati-781035, India.
Department of Pharmaceutical Chemistry, M.R. College of Pharmaceutical Sciences and Research, Balisha-743234, India.
Int J Biol Macromol. 2025 Feb;290:138678. doi: 10.1016/j.ijbiomac.2024.138678. Epub 2024 Dec 11.
With cancer rates on the rise around the world, cancer treatment has dominated scientific discussions in recent years. The toxicity of cytotoxic drugs, their lack of tumor localization, and their uniform dispersion into tumor tissues are the obstacles to cancer therapy. Other cancer treatment drawbacks include short blood circulation half-lives and undesirable pharmacokinetic behavior. Low-molecular-weight drugs conjugated with macromolecular carriers are better distributed in the body. The enhanced permeation and retention (EPR) effect causes natural and synthetic polymers, such as polysaccharides, proteins, antibodies, and poly amino acids, to accumulate in tumor tissue. Many manufactured and natural polymers are attractive polymeric drug carriers, allowing the creation of prodrugs from medicinal substances. Polysaccharides are biological polymers with structural and functional variations. They are also non-toxic, hydrophilic, biodegradable, and efficiently bioactive. Polysaccharides are ideal for synthesizing many nanoparticles due to their functional groups. Their ability to adapt to their microenvironment makes them valuable. Nanoplatforms based on polysaccharides can deliver targeted anticancer drugs for personalized cancer treatment. Unique polysaccharide structures and properties offer chemical and biological advantages for novel drug delivery. Polysaccharide-drug conjugation could revolutionize cancer chemotherapy. This study investigates polysaccharide conjugates and polysaccharides as natural biomaterials for cancer drug delivery.
随着全球癌症发病率的上升，癌症治疗近年来主导了科学讨论。细胞毒性药物的毒性、缺乏肿瘤定位以及它们在肿瘤组织中的均匀分散是癌症治疗的障碍。癌症治疗的其他缺点包括血液循环半衰期短和不良的药代动力学行为。与大分子载体缀合的低分子量药物在体内分布更好。增强的渗透和滞留（EPR）效应使天然和合成聚合物，如多糖、蛋白质、抗体和聚氨基酸，在肿瘤组织中积累。许多人工合成和天然聚合物都是有吸引力的聚合物药物载体，能够从药用物质中制备前药。多糖是具有结构和功能多样性的生物聚合物。它们也是无毒、亲水、可生物降解且具有高效生物活性的。由于其官能团，多糖是合成许多纳米颗粒的理想材料。它们适应微环境的能力使其具有价值。基于多糖的纳米平台可以递送靶向抗癌药物用于个性化癌症治疗。独特的多糖结构和性质为新型药物递送提供了化学和生物学优势。多糖-药物缀合可能会彻底改变癌症化疗。本研究调查多糖缀合物和多糖作为用于癌症药物递送的天然生物材料。
