Zhang Nan, Wang Xinjia, Li Yu, Lu Yiwei, Sheng Chengcheng, Sun Yumeng, Ma Ningye, Jiao Yisheng
Shengjing Hospital of China Medical University, Obstetrics and Gynecology Department, NO36. Sanhao Street, Heping district, Shenyang, China.
Commun Biol. 2025 Jan 17;8(1):77. doi: 10.1038/s42003-024-07383-z.
Circular RNAs (circRNAs) have garnered substantial attention due to their distinctive circular structure and gene regulatory functions, establishing them as a significant class of functional non-coding RNAs in eukaryotes. Studies have demonstrated that circRNAs can interact with RNA-binding proteins (RBPs), which play crucial roles in tumorigenesis, metastasis, and drug response in cancer by influencing gene expression and altering the processes of tumor initiation and progression. This review aims to summarize the recent advances in research on circRNA-protein interactions (CPIs) and discuss the functions and mode of action of CPIs at various stages of gene expression, including transcription, splicing, translation, and post-translational modifications in the context of cancer. Additionally, we explore the role of CPIs in tumor drug resistance to gain a deeper understanding of their potential applications in the development of new anti-cancer therapeutic approaches.
环状RNA（circRNAs）因其独特的环状结构和基因调控功能而备受关注，使其成为真核生物中一类重要的功能性非编码RNA。研究表明，circRNAs可与RNA结合蛋白（RBPs）相互作用，这些蛋白通过影响基因表达以及改变肿瘤起始和进展过程，在肿瘤发生、转移和癌症药物反应中发挥关键作用。本综述旨在总结环状RNA-蛋白质相互作用（CPIs）研究的最新进展，并讨论CPIs在基因表达各个阶段（包括癌症背景下的转录、剪接、翻译和翻译后修饰）的功能及作用模式。此外，我们还探讨了CPIs在肿瘤耐药性中的作用，以更深入了解其在开发新的抗癌治疗方法中的潜在应用。
