Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, 315211, China.
J Mol Med (Berl). 2024 Nov;102(11):1297-1314. doi: 10.1007/s00109-024-02488-8. Epub 2024 Sep 17.
Circular RNAs (circRNAs) are an interesting class of conserved single-stranded RNA molecules derived from exon or intron sequences produced by the reverse splicing of precursor mRNA. CircRNAs play important roles as microRNA sponges, gene splicing and transcriptional regulators, RNA-binding protein sponges, and protein/peptide translation factors. Abnormal functions of circRNAs and RBPs in tumor progression have been widely reported. Insulin-like growth factor-2 mRNA-binding proteins (IGF2BPs) are a highly conserved family of RBPs identified in humans that function as post-transcriptional fine-tuners of target transcripts. Emerging evidence suggests that IGF2BPs regulate the processing and metabolism of RNA, including its stability, translation, and localization, and participate in a variety of cellular functions and pathophysiology. In this review, we have summarized the roles and molecular mechanisms of circRNAs and IGF2BPs in cancer development and progression. In addition, we briefly introduce the role of other RNAs and IGF2BPs in cancer, discuss the current clinical applications and challenges faced by circRNAs and IGF2BPs, and propose future directions for this promising research field.
环状 RNA（circRNAs）是一类有趣的保守的单链 RNA 分子，来源于前体 mRNA 通过反向剪接产生的外显子或内含子序列。circRNAs 作为 microRNA 海绵、基因剪接和转录调控因子、RNA 结合蛋白海绵以及蛋白质/肽翻译因子发挥重要作用。circRNAs 和 RBP 在肿瘤进展中的异常功能已被广泛报道。胰岛素样生长因子 2 mRNA 结合蛋白（IGF2BPs）是在人类中发现的高度保守的 RBP 家族，作为靶转录物的转录后精细调节剂发挥作用。新出现的证据表明，IGF2BPs 调节 RNA 的加工和代谢，包括其稳定性、翻译和定位，并参与多种细胞功能和病理生理学。在这篇综述中，我们总结了 circRNAs 和 IGF2BPs 在癌症发生和发展中的作用和分子机制。此外，我们还简要介绍了其他 RNA 和 IGF2BPs 在癌症中的作用，讨论了 circRNAs 和 IGF2BPs 面临的当前临床应用和挑战，并为这一有前途的研究领域提出了未来的方向。
