Andrysek O, Bláhová E, Gregora V, Rezný Z
Neoplasma. 1985;32(1):93-101.
A simple prediction test for a combination of hyperthermia and chemotherapy checked on three experimental tumors and cells of the normal murine thymus is described. The testing procedure is based on checking the incorporation of labeled 125I 5-iodo-2-deoxyuridine into the DNA of tested cells affected solely by the enhanced temperature or by the cytostatic itself, or by a combination of both agents. The statistical analysis of repeated results demonstrated the reproducibility of the test. Testing of the potentiation effect of different non-cytostatic substances with enhanced temperatures also gave results corresponding to findings of other authors, performed in vivo or by the use of other techniques. Thus, this simple method is recommended for a screening, before considering the individual use of the combination of hyperthermia and chemotherapy in patients.
描述了一种针对热疗与化疗联合作用的简单预测试验，该试验在三种实验性肿瘤以及正常小鼠胸腺细胞上进行了检验。测试程序基于检查标记的125I 5-碘-2-脱氧尿苷掺入仅受升高温度、细胞抑制剂本身或两种药物联合作用影响的受试细胞的DNA中。对重复结果的统计分析证明了该试验的可重复性。对不同非细胞抑制剂物质在升高温度下的增效作用进行测试，所得结果也与其他作者在体内或使用其他技术所做研究的结果相符。因此，在考虑对患者单独使用热疗与化疗联合治疗之前，推荐使用这种简单方法进行筛查。
