Jin Yuanli, Gong Tao, Lu Xiaoxi, Wang Yizhen, Cheng Yuanzhi
National Engineering Research Center of Green Feeds and Healthy Livestock Industry, Hangzhou, 310058, Zhejiang, China.
Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Hangzhou, 310058, Zhejiang, China.
Appl Microbiol Biotechnol. 2025 Jan 18;109(1):10. doi: 10.1007/s00253-024-13400-2.
The widespread use of antibiotics has led to the emergence of multidrug-resistant bacteria, which pose significant threats to animal health and food safety. Host defense peptides (HDPs) have emerged as promising alternatives because of their unique antimicrobial properties and minimal resistance induction. However, the high costs associated with HDP production and incorporation into animal management practices hinder their widespread application. Alternatively, promoting endogenous HDP expression has gained attention as a sustainable and cost-effective approach. This study summarizes the latest research findings on the modulation of HDP expression by the gut microbiota and its metabolites. By exploring the intricate relationships among the gut microbiota, metabolites, and HDP expression, this study aims to provide a theoretical foundation for the development of targeted strategies to increase endogenous HDP production, thereby promoting animal health and resistance to infectious diseases. KEY POINTS: • Host defense peptides (HDPs) are expressed via various factors, such as nutrients, the gut microbiota, and microbial metabolites. • Recent trends include mechanisms among the gut microbiota, microbiota metabolites, and the intestine on HDP expression. • A comprehensive overview of mechanisms of HDP expression and gut microbiota-host interaction is provided.
抗生素的广泛使用导致了多重耐药菌的出现，这对动物健康和食品安全构成了重大威胁。宿主防御肽（HDPs）因其独特的抗菌特性和极低的耐药性诱导而成为有前景的替代物。然而，与HDP生产以及将其纳入动物管理实践相关的高成本阻碍了它们的广泛应用。另外，促进内源性HDP表达作为一种可持续且具有成本效益的方法受到了关注。本研究总结了关于肠道微生物群及其代谢产物对HDP表达调控的最新研究结果。通过探索肠道微生物群、代谢产物和HDP表达之间的复杂关系，本研究旨在为制定增加内源性HDP产生的靶向策略提供理论基础，从而促进动物健康和对传染病的抵抗力。要点：• 宿主防御肽（HDPs）通过多种因素表达，如营养物质、肠道微生物群和微生物代谢产物。• 近期趋势包括肠道微生物群、微生物群代谢产物和肠道之间对HDP表达的作用机制。• 提供了HDP表达机制以及肠道微生物群与宿主相互作用的全面概述。
