Shafiee Mohsen, Soltani Fard Elahe, Taghvimi Sina, Movahedpour Ahmad, Mousavi Pegah, Rezaeijo Seyed Masoud, Khatami Seyyed Hossein, Azadbakht Omid
Department of Nursing, Abadan University of Medical Sciences, Abadan, Iran.
Department of Molecular Medicine, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Appl Radiat Isot. 2025 Apr;218:111671. doi: 10.1016/j.apradiso.2025.111671. Epub 2025 Jan 12.
For men with localized prostate cancer, radiotherapy (RT) remains a common therapeutic option. Although radiotherapy has had significant success, it remains an intractable issue in promoting radiation damage to tumor tissue while reducing adverse effects on healthy tissue. Chemicals or pharmacological substances known as radiosensitizers can increase the killing effect on tumor cells by accelerating DNA damage and indirectly producing free radicals. Of all the approaches to improving RT management outcomes, metal nanoparticle-enhanced radiation for prostate cancer patient therapy is a unique strategy that has sparked scientific attention in the past decade. Most current data is based on targeted RT with gold nanoparticles, among the most studied materials. Nevertheless, several novel materials have also been employed in preclinical settings. This study assesses existing dosimetric data on prostate cancer tissue as well as the likely future influence on treatment options and patient outcomes since further research in a clinical setting is necessary.
对于局限性前列腺癌男性患者，放射治疗（RT）仍是一种常见的治疗选择。尽管放射治疗已取得显著成效，但在促进肿瘤组织的辐射损伤同时减少对健康组织的不良影响方面，它仍然是一个棘手的问题。被称为放射增敏剂的化学物质或药理物质可通过加速DNA损伤和间接产生自由基来增强对肿瘤细胞的杀伤作用。在改善放射治疗管理结果的所有方法中，金属纳米颗粒增强辐射用于前列腺癌患者治疗是一种独特的策略，在过去十年中引起了科学界的关注。目前的大多数数据基于使用金纳米颗粒的靶向放射治疗，金纳米颗粒是研究最多的材料之一。然而，一些新型材料也已用于临床前研究。本研究评估了前列腺癌组织现有的剂量学数据，以及对治疗选择和患者预后可能产生的未来影响，因为在临床环境中进行进一步研究是必要的。
