Younkin D, Hungerbuhler J P, O'Connor M, Goldberg H, Burke A, Kushner M, Hurtig H, Obrist W, Gordon J, Gur R
Neurology. 1985 Apr;35(4):462-9. doi: 10.1212/wnl.35.4.462.
In 44 patients, we studied the effects of superficial temporal-middle cerebral artery anastomosis on cerebral blood flow (CBF), neurologic examination, and cognitive functions. At 3 months, there was significant improvement in all variables. At 9 months, CBF was no longer significantly greater, but neurologic examination and cognitive functions had further improved. Patients with TIA had significant postoperative decreases in TIA frequency and did not progress to stroke, but had no significant changes in any variable. In stroke patients, we could not separate the effects of surgery from the natural evolution of changes in CBF and examination after stroke. None of the preoperative measurements predicted postoperative clinical improvement.
在44例患者中，我们研究了颞浅动脉-大脑中动脉吻合术对脑血流量（CBF）、神经学检查及认知功能的影响。3个月时，所有变量均有显著改善。9个月时，脑血流量不再显著增加，但神经学检查及认知功能进一步改善。短暂性脑缺血发作（TIA）患者术后TIA发作频率显著降低，且未进展为卒中，但在任何变量上均无显著变化。对于卒中患者，我们无法区分手术效果与卒中后脑血流量变化及检查的自然演变。术前测量均无法预测术后临床改善情况。
