Nguyen Tung D, Winek Michael A, Rao Mihir K, Dhyani Shaiva P, Lee Monica Y
Department of Physiology and Biophysics, The University of Illinois at Chicago - College of Medicine, Chicago, IL, USA.
The Center for Cardiovascular Research, The University of Illinois at Chicago - College of Medicine, Chicago, IL, USA.
Nucleus. 2025 Dec;16(1):2453752. doi: 10.1080/19491034.2025.2453752. Epub 2025 Jan 19.
The vascular network, uniquely sensitive to mechanical changes, translates biophysical forces into biochemical signals for vessel function. This process relies on the cell's architectural integrity, enabling uniform responses to physical stimuli. Recently, the nuclear envelope (NE) has emerged as a key regulator of vascular cell function. Studies implicate nucleoskeletal elements ( nuclear lamina) and the linker of nucleoskeleton and cytoskeleton (LINC) complex in force transmission, emphasizing nucleo-cytoskeletal communication in mechanotransduction. The nuclear pore complex (NPC) and its component proteins ( nucleoporins) also play roles in cardiovascular disease (CVD) progression. We herein summarize evidence on the roles of nuclear lamina proteins, LINC complex members, and nucleoporins in endothelial and vascular cell mechanotransduction. Numerous studies attribute NE components in cytoskeletal-related cellular behaviors to insinuate dysregulation of nucleocytoskeletal feedback and nucleocytoplasmic transport as a mechanism of endothelial and vascular dysfunction, and hence implications for aging and vascular pathophysiology.
血管网络对机械变化具有独特的敏感性，它将生物物理力转化为血管功能的生化信号。这一过程依赖于细胞的结构完整性，从而实现对物理刺激的统一反应。最近，核膜（NE）已成为血管细胞功能的关键调节因子。研究表明，核骨架成分（核纤层）以及核骨架与细胞骨架连接复合体（LINC）参与力的传递，强调了机械转导中的核-细胞骨架通讯。核孔复合体（NPC）及其组成蛋白（核孔蛋白）在心血管疾病（CVD）进展中也发挥作用。我们在此总结了关于核纤层蛋白、LINC复合体成员和核孔蛋白在内皮细胞和血管细胞机械转导中作用的证据。众多研究将核膜成分在细胞骨架相关细胞行为中的作用归因于核-细胞骨架反馈和核质运输失调，这是内皮细胞和血管功能障碍的一种机制，因此对衰老和血管病理生理学具有重要意义。
