Lin X Q, Lin X R, Yang C L, Wang X Y, Ouyang J, Guan Q, Huang S F, Yin Y R, Liang D, Zhong W L
Department for Chronic and Non-communicable Disease Control and Prevention, Fujian Provincial Center for Disease Control and Prevention, Fuzhou350000, China.
School of Public Health, Fujian Medical University, Fuzhou350000, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2025 Jan 10;46(1):57-64. doi: 10.3760/cma.j.cn112338-20240516-00280.
To understand the burden of chronic kidney disease (CKD) and its risk factors in Fujian Province during 1990-2019. Based on the Global Burden of Disease Study 2019, the incidence rate, mortality rate and disability-adjusted life years (DALYs) of CKD in Fujian from 1990 to 2019 were calculated. An age-period-cohort model was used to estimate the effects of age, period, and cohort on age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized DALY rate (ASDR) of CKD. Comparative risk assessment theory was used to calculate the potential attributable DALYs due to risk factors. In 2019, the ASIR of CKD in Fujian exceeded the national average. The ASIR of CKD showed an increasing trend from 1990 to 2019, but the ASMR and ASDR of CKD exhibited decreasing trends during the same period. In 2019, the ASIR of CKD was higher in women than in men, while the ASMR and ASDR were higher in men than in women. Age-period-cohort analysis indicated that ASIR, ASMR, and ASDR of CKD increased with age. The period effect for ASIR decreased first before increase, while the period effect for ASMR and ASDR displayed fluctuating trends. The cohort effect showed an upward trajectory for ASIR, but a stable status before downward trajectories for ASMR and ASDR. Compared with 1990, except the increase in the ASDR of CKD attributed to high BMI and high temperatures, the ASDR of CKD attributed to other risk factors all showed decreases in 2019. However, the ASDR attributed to high sodium intake remained higher compared with the global average. The burden of CKD remains heavy in Fujian, and it is necessary to reduce the attributable risk factors, such as high sodium intake and high BMI, to address this problem.
了解1990 - 2019年福建省慢性肾脏病（CKD）的负担及其风险因素。基于《2019年全球疾病负担研究》，计算了1990年至2019年福建省CKD的发病率、死亡率和伤残调整生命年（DALYs）。采用年龄-时期-队列模型估计年龄、时期和队列对CKD年龄标准化发病率（ASIR）、年龄标准化死亡率（ASMR）和年龄标准化DALY率（ASDR）的影响。运用比较风险评估理论计算风险因素导致的潜在归因DALYs。2019年，福建省CKD的ASIR超过全国平均水平。1990年至2019年CKD的ASIR呈上升趋势，但同期CKD的ASMR和ASDR呈下降趋势。2019年，CKD的ASIR女性高于男性，而ASMR和ASDR男性高于女性。年龄-时期-队列分析表明，CKD的ASIR、ASMR和ASDR随年龄增长而增加。ASIR的时期效应先下降后上升，而ASMR和ASDR的时期效应呈波动趋势。队列效应显示ASIR呈上升轨迹，但ASMR和ASDR在下降轨迹之前呈稳定状态。与1990年相比，2019年除高体重指数（BMI）和高温导致的CKD的ASDR增加外，其他风险因素导致的CKD的ASDR均呈下降趋势。然而，高钠摄入导致的ASDR仍高于全球平均水平。福建省CKD负担仍然较重，有必要减少高钠摄入和高BMI等可归因风险因素以解决这一问题。
