Frumuzachi Oleg, Kieserling Helena, Rohn Sascha, Mocan Andrei
Department of Food Chemistry and Analysis, Institute of Food Technology and Food Chemistry, Technische Universität Berlin, Berlin, Germany.
Department of Pharmaceutical Botany, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Crit Rev Food Sci Nutr. 2025 Jan 19:1-21. doi: 10.1080/10408398.2025.2453090.
The so-called Mediterranean diet, with olive oil as a key component, is effective in reducing cardiometabolic disease risk. Olive oil consumption improves blood pressure, insulin levels and resistance, supporting heart health and glycemic control. Its phenolic compounds, including oleuropein (OLE), hydroxytyrosol (HT), and tyrosol (TYR) are hypothesized to likely contribute to these benefits. Thus, this meta-analysis evaluated the clinical effects of dietary supplementation with OLE, HT, and TYR on cardiometabolic outcomes. Fourteen human intervention studies with 594 participants were included. The analysis using a random-effects model showed that OLE, HT, and TYR significantly reduced total cholesterol (SMD = -0.19, CI: -0.37 to -0.01, = 0.04, = 35%), triacylglycerol (SMD = -0.32, CI: -0.60 to -0.03, = 0.03, = 73%), and insulin (SMD = -0.42, CI: -0.82 to -0.01, = 0.04, = 78%). Subgroup analysis showed that, in certain contexts, interventions may be more beneficial for BMI <30, non-Mediterranean, and cardiometabolic disease individuals, while intervention compound, type of intervention, and duration might have differential effects regarding considered outcomes. Overall, the meta-analysis suggests that supplementation with OLE, HT, and TYR may beneficially impact some cardiometabolic parameters, though further studies are needed to confirm these findings.
以橄榄油为关键成分的所谓地中海饮食，在降低心脏代谢疾病风险方面很有效。食用橄榄油可改善血压、胰岛素水平及胰岛素抵抗，有助于心脏健康和血糖控制。据推测，其酚类化合物，包括橄榄苦苷（OLE）、羟基酪醇（HT）和酪醇（TYR）可能是这些益处的成因。因此，本荟萃分析评估了补充OLE、HT和TYR对心脏代谢指标的临床效果。纳入了14项有594名参与者的人体干预研究。采用随机效应模型的分析表明，OLE、HT和TYR显著降低了总胆固醇（标准化均数差[SMD]= -0.19，95%置信区间[CI]：-0.37至-0.01，P = 0.04，I² = 35%）、甘油三酯（SMD = -0.32，CI：-0.60至-0.03，P = 0.03，I² = 73%）和胰岛素（SMD = -0.42，CI：-0.82至-0.01，P = 0.04，I² = 78%）。亚组分析表明，在某些情况下，干预措施可能对体重指数（BMI）<30的人、非地中海地区的人和患有心脏代谢疾病的人更有益，而干预化合物、干预类型和持续时间可能对所考虑的指标有不同影响。总体而言，该荟萃分析表明，补充OLE、HT和TYR可能对某些心脏代谢参数产生有益影响，不过还需要进一步研究来证实这些发现。
