Schanzer H, Jacobson J H
Pediatrics. 1985 Apr;75(4):741-4.
In order to elucidate whether tissue damage produced on occasion by intramuscular injection of long-acting penicillin is due to accidental intra-arterial injection or vasospasm, two types of experiments were carried out in rabbits. In the first set of experiments, six New Zealand White rabbits were given intra-arterial injections of 0.4 mL of a mixture containing 300,000 U of penicillin G benzathine and 300,000 units of penicillin procaine per milliliter (Bicillin C-R) into the left femoral artery and 0.4 mL of normal saline into the right femoral artery as autocontrol. In a second set of experiments, 0.4 mL of the same penicillin preparation was injected in the space surrounding the left femoral artery in five New Zealand rabbits, and 0.4 mL of normal saline was injected in a similar fashion around the right femoral artery as control. The legs of the rabbits that received the intra-arterial injection of penicillin invariably developed ischemic manifestations. None of the legs of rabbits given intra-arterial injections of normal saline had pathologic manifestations. None of the rabbits that received the periarterial penicillin preparation or normal saline developed abnormalities. These results strongly suggest that the tissue damage produced by penicillin is secondary to the intra-arterial administration of the drug.
为了阐明偶尔因肌内注射长效青霉素所产生的组织损伤是由于意外动脉内注射还是血管痉挛所致，在兔子身上进行了两种类型的实验。在第一组实验中，给6只新西兰白兔的左股动脉内注射0.4 mL每毫升含30万单位苄星青霉素G和30万单位普鲁卡因青霉素的混合液（苄星青霉素C-R），右股动脉内注射0.4 mL生理盐水作为自身对照。在第二组实验中，给5只新西兰白兔在左股动脉周围间隙注射0.4 mL相同的青霉素制剂，以类似方式在右股动脉周围注射0.4 mL生理盐水作为对照。接受动脉内注射青霉素的兔子的腿部总是出现缺血表现。接受动脉内注射生理盐水的兔子的腿部均无病理表现。接受动脉周围青霉素制剂或生理盐水注射的兔子均未出现异常。这些结果有力地表明，青霉素产生的组织损伤是药物动脉内给药的继发结果。
