Malota H, Jezdinský J, Dusek J
Z Gesamte Inn Med. 1983 Aug 1;38(15):425-9.
Own investigations concerning the principal mechanisms of Hoigné's syndrome demonstrated that the phenomenology of embolotoxic reactions depends in certain pre-conditions on high pressure during a rapid injection with the result of penetration of the drug into the blood stream. The occurrence of the syndrome and its symptomatology depend on the size of the crystals or lipid droplets that enter the blood stream, on the solubility of the crystals in the body, on the toxicity of the components of a particular drug and on the volume of the injected drug that enters the blood vessels. For the reasons mentioned above the symptomatology of the syndrome is variable and depends on the type of medicament applied.
我自己关于霍伊内综合征主要机制的研究表明，栓塞毒性反应的现象学在某些先决条件下取决于快速注射过程中的高压，导致药物进入血流。该综合征的发生及其症状取决于进入血流的晶体或脂质小滴的大小、晶体在体内的溶解度、特定药物成分的毒性以及进入血管的注射药物的体积。由于上述原因，该综合征的症状是可变的，并取决于所应用药物的类型。
