Snapyan Marta, Desmeules Francis, Munro Jonathan, Bérard Morgan, Saikali Stephan, Gould Peter V, Richer Maxime, Pourcher Emmanuelle, Langlois Mélanie, Dufresne Anne-Marie, Prud'homme Michel, Cantin Léo, Parent André, Saghatelyan Armen, Parent Martin
CERVO Brain Research Centre, Quebec City, Quebec, Canada.
Hôpital de l'Enfant-Jésus, CHU de Québec-Université Laval, Quebec City, Quebec, Canada.
Ann Neurol. 2025 May;97(5):894-906. doi: 10.1002/ana.27181. Epub 2025 Jan 19.
Parkinson's and Huntington's diseases are characterized by progressive neuronal loss. Previous studies using human postmortem tissues have shown the impact of neurodegenerative disorders on adult neurogenesis. The extent to which adult neural stem cells are activated in the subventricular zone and whether therapeutic treatments such as deep brain stimulation promote adult neurogenesis remains unclear. The goal of the present study is to assess adult neural stem cells activation and neurogenesis in the subventricular zone of patients with Huntington's and Parkinson's diseases who were treated or not by deep brain stimulation.
Postmortem brain samples from Huntington's and Parkinson's disease patients who had received or not long-term deep brain stimulation of the subthalamic nucleus were used.
Our results indicate a significant increase in the thickness of the subventricular zone and in the density of proliferating cells and activated stem cells in the brain of Huntington's disease subjects and Parkinson's disease patients treated with deep brain stimulation. We also observed an increase in the density of immature neurons in the brain of these patients.
Overall, our data indicate that long-term deep brain stimulation of the subthalamic nucleus promotes cell proliferation and neurogenesis in the subventricular zone that are reduced in Parkinson's disease. Taken together, our results also provide a detailed characterization of the cellular composition of the adult human subventricular zone and caudate nucleus in normal condition and in Parkinson's and Huntington's diseases and demonstrate the plasticity of these regions in response to neurodegeneration. ANN NEUROL 2025;97:894-906.
帕金森病和亨廷顿病的特征是神经元进行性丧失。先前使用人类尸检组织的研究已显示神经退行性疾病对成体神经发生的影响。成人神经干细胞在脑室下区被激活的程度以及诸如深部脑刺激等治疗方法是否能促进成体神经发生仍不清楚。本研究的目的是评估接受或未接受深部脑刺激治疗的亨廷顿病和帕金森病患者脑室下区的成人神经干细胞激活和神经发生情况。
使用来自接受或未接受丘脑底核长期深部脑刺激的亨廷顿病和帕金森病患者的尸检脑样本。
我们的结果表明，在接受深部脑刺激治疗的亨廷顿病受试者和帕金森病患者的大脑中，脑室下区的厚度、增殖细胞和激活干细胞的密度显著增加。我们还观察到这些患者大脑中未成熟神经元的密度增加。
总体而言，我们的数据表明，丘脑底核的长期深部脑刺激可促进帕金森病中减少的脑室下区的细胞增殖和神经发生。综上所述，我们的结果还详细描述了正常状态以及帕金森病和亨廷顿病中成人人类脑室下区和尾状核的细胞组成，并证明了这些区域对神经退行性变的可塑性反应。《神经病学年鉴》2025年；97:894 - 906。
