Bagger-Jörgensen Harald, Thomsen Christian, Borrisholt Martine, Wanders Alkwin, Sjöberg Klas
Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö, Sweden.
APMIS. 2025 Jan;133(1):e70000. doi: 10.1111/apm.70000.
The role of the vitamin D receptor (VDR) in inflammatory bowel disease (IBD) is poorly described. The aim of this study was to examine the relationship between immunohistochemical VDR expression and IBD activity. The immunohistochemical expression of VDR was analysed in biopsies from active and inactive IBD in 28 patients (ulcerative colitis: 21, Crohn's disease: 7) and 12 non-IBD controls. VDR expression did not change in active compared to inactive disease (p = 0.40 in epithelium and p = 0.29 in stroma). There was a trend for higher VDR expression in controls compared to IBD patients. No relationship was found between VDR expression and histologic inflammation (r = -0.19, p = 0.89 for epithelium and r = 0.13, p = 0.35 for stroma), colonoscopic picture and clinical and laboratory measures including serum 25(OH) vitamin D status (r = -0.91, p = 0.82). IBD disease activity did not correlate to VDR immunohistochemical expression, nor did it differ compared to controls. These results partly conflict with prior studies, but these have only shown modest correlations. Prospective studies investigating VDR activity between IBD and controls should be contemplated.
维生素D受体（VDR）在炎症性肠病（IBD）中的作用鲜有描述。本研究旨在探讨免疫组化VDR表达与IBD活动度之间的关系。分析了28例患者（溃疡性结肠炎：21例，克罗恩病：7例）活动期和非活动期IBD活检组织以及12例非IBD对照的VDR免疫组化表达。与非活动期疾病相比，活动期疾病的VDR表达无变化（上皮细胞中p = 0.40，基质中p = 0.29）。与IBD患者相比，对照组VDR表达有升高趋势。未发现VDR表达与组织学炎症（上皮细胞r = -0.19，p = 0.89；基质r = 0.13，p = 0.35）、结肠镜图像以及包括血清25(OH)维生素D状态在内的临床和实验室指标之间存在相关性（r = -0.91，p = 0.82）。IBD疾病活动度与VDR免疫组化表达无关，与对照组相比也无差异。这些结果部分与先前研究相矛盾，但先前研究仅显示出适度的相关性。应考虑开展关于IBD与对照之间VDR活性的前瞻性研究。
